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Inhibition of PI3K or mTOR reduced ligustrazine-mediated protection of RGCs after I/R injury. RGCs with retinal I/R injury were treated with 10 μg/mL ligustrazine alone or with 10 µM Ly294002 or 10 μM rapamycin. **p< 0.01 vs. normal group; ##p< 0.01 vs. model group. $$p< 0.01 vs. ligustrazine group
