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. 2021 Oct 27;12(1):8753–8767. doi: 10.1080/21655979.2021.1982230

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Upregulation of miR-296-5p counteracted the enhancing effects of overexpressed KCNQ1OT1 on the proliferative, migrative and invasive abilities of CC cells. (a) RT-qPCR for determination of KCNQ1OT1 level in SiHa cells after transfection with pcDNA-KCNQ1OT1 or co-transfection with miR-296-5p mimic. (b) CCK-8 assay examined the influence of miR-296-5p elevation on the enhanced proliferative ability of CC cells caused by KCNQ1OT1 overexpression. (c, d) Wound healing assay determined the influence of miR-296-5p elevation on the enhanced migrative ability of CC cells caused by KCNQ1OT1 overexpression. (e, f) Transwell assay detected the influence of miR-296-5p elevation on the enhanced invasive ability of CC cells caused by KCNQ1OT1 overexpression. (g) Western blotting analysis assessed the influence of miR-296-5p elevation on the increased expressions of MMP2 and MMP9 in CC cells caused by KCNQ1OT1 overexpression