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Ibrutinib decreased oxidative stress and inflammatory response in I/R injured brain tissue of diabetic mice. The injured lateral hemispheres were processed for detection of (a) IL-1β, (b) IL-6, and (c) TNF-α concentrations. Brain tissues were processed for detection of (d) SOD, (e) MDA, and (f) ROS levels. Data presented as mean SD, n = 8/group. *P < 0.05 vs. the DS group, #P < 0.05 vs. the DIR group
