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Icariin potently suppressed PI3K/AKT/mTOR signaling in cartilage tissues. Western blotting was used to measure the protein levels of PI3K, p-AKT1, AKT1, p-mTOR, mTOR, p70S6K, and p-p70S6K in cartilage tissues. PI3K, p-AKT1/AKT1, p-mTOR/mTOR, and p70S6K/p-p70S6K levels were significantly suppressed in the rapamycin and icariin groups (**p < 0.01 vs. Sham, ##p < 0.01 vs. OA). Data are presented as means ± SD (n = 6)
