Figure 3.

Hsa_circ_0005567 regulates SOCS2 expression by miR-492. (a-b) The binding regulation ship of hsa_circ_0005567 and miR-492 was identified by RNA pull-down. (c) Luciferase activity assay was used to identify the binding of miR-492 to SOCS2 3ʹUTR. (d) Overexpression of hsa_circ_0005567 reversed LPS-increased miR-492 expression. (e-f) Overexpression of hsa_circ_0005567 reversed LPS-decreased SOCS2 expression. **p < 0.01 vs NC group, ^##p < 0.01 vs Bio-NC group, ^$$p < 0.01 vs mimic NC group, ^&&p < 0.01 vs Control group, ^@@p < 0.01 vs Vector+ LPS group