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. 2022 Jan 10;75:103776. doi: 10.1016/j.ebiom.2021.103776

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© 2021 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig 3 — Detailed mechanistic characterization of the poor prognosis NPS and INF endotypes. (a) Functional enrichment of up- and down- regulated DE genes when comparing the NPS endotype to all other endotypes combined and the INF endotype to all others. (b) Fold changes of genes associated to NPS and INF related processes, which reflect potential mediators and regulators of the endotype. The NPS endotype is clearly immunosuppressed as indicated by the downregulation of several processes, including inflammation, interferon processes, and PD-1 signaling among others.