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. 2020 Dec 17;13(1 Suppl):1598S–1609S. doi: 10.1177/1947603520980161

Figure 3.

Figure 3.

Micro-computed tomography (micro-CT) analysis of tibial subchondral plate and subchondral bone. (A) Demographic image of coronal view of region of interest (ROI) selection of medial and lateral tibial subchondral bone plate. (B) Quantitative analysis of subchondral plate porosity. (C) Demographic image of coronal view of ROI selection of medial and lateral tibial subchondral bone. (D) Reconstructed cross-sections through the intact knee joint (femur and tibia) showing significant reduction in bone porosity and increased bone formation (Inline graphic) in subchondral trabecular bone of WNIN/Gr-Ob rats compared with WNIN rats at 6 and 9 months of age. Values are expressed as mean ± SD (n = 6). *P < 0.05; **P < 0.01. Comparisons were made against age-matched WNIN controls.