Figure 6.

miR-635 directly targets NLRP3. (a) The binding sites of miR-635 on NLRP3 3′-UTR. (b) The luciferase activity of HAECs co-transfected with luciferase reporter vector containing NLRP3 3′-UTR and miR-635 overexpression vector. (c) The interaction between miR-635 and NLRP3. (d) Expression of NLRP3 in HAECs with miR-635 knockdown. (e) Expression of NLRP3 in HAECs cells under indicated conditions. **P < 0.01 versus vector, si-NC, biotin-NC or control. nc inhibitor, blank vector; inhibitor, knockdown of miR-635