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. 2022 Jan 5;602(7895):135–141. doi: 10.1038/s41586-021-04265-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Manual mapping of the tips on the type XI SCCmec phylogeny onto the CC130, CC425 and CC1943 phylogenies, and vice versa, enabled us to assign the mecC-MRSA isolates to 16 monophyletic lineages containing orthologous type XI SCCmec elements (A–G). The trees are redrawn from Supplementary Figs. 2–5 to illustrate the branching order of the different type XI SCCmec variants and mecC-MRSA lineages. Branch lengths are not drawn to scale. The presence and absence of hedgehog isolates in a given lineage are shown as black and white boxes, respectively. A detailed description of the geographical distribution and host range of major mecC-MRSA CC130, CC425 and CC1943 lineages is provided in Extended Data Fig. 7. The estimated date of the most recent common ancestor and 95% confidence interval of each mecC-MRSA lineage are illustrated by filled circles and horizontal lines, respectively. The introduction of penicillin G and methicillin as therapeutic options is indicated by red lines.

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