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. 2022 Jan 12;602(7895):101–105. doi: 10.1038/s41586-021-04269-6

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© The Author(s) 2022, corrected publication 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — a, Enrichment of features in coding sequences of “lethal-effect” genes (n = 2,720 lethal-effect genes, mean ±2 s.e.m.). b, Total mutation rate (±2 s.e.m., bootstrapped) in lethal- and non-lethal-effect genes (n = 27,206 genes). c, Enrichment of features in coding sequences of constitutively (across all tissues) expressed genes (n = 9,957 genes, mean ± 2 s.e.m.). d, Total mutation rate (±2 s.e.m., bootstrapped) in genes binned according to the number of tissues in which they are expressed (n = 25,987 genes with tissue-specific expression data)³⁹.