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. Author manuscript; available in PMC: 2022 Feb 3.
Published in final edited form as: Anaerobe. 2019 Nov 21;61:102129. doi: 10.1016/j.anaerobe.2019.102129

Figure 2. Inhibition of murA and murC gene activity affects C. difficile sporulation.

Figure 2

Spore production was analyzed at day 5, following induction by anhydrotetracycline (ATc) of antisenses to murA (A), murC (B) and spo0A (C). (D) Comparison of inhibition of sporulation by fosfomycin (FOS [MIC = 8 μ g/mL]) and vancomycin (VAN [MIC = 0.25 μg/mL]). Acridine orange (AO) served as a positive control. Data from four biological replicates were analyzed by t-test in GraphPad prism 8 and significance at p<0.01 and p<0.001 are shown by asterisks.