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Pathogenicity of KNU18-91 isolate in vivo. Female BALB/c mice were challenged with 104 EID50/mL of virus by intranasal inoculation. The H1N1 subtype was used as the control. Mice survival rate (a) and body weight (b) were observed daily for 14 dpi. Body weight is shown as a percentage of that in mice before inoculation (n = 10). Mean virus titers in the lung of mice (n = 3) were determined at 3, 6, and 14 dpi (c). **, p < 0.01. EID50, 50% egg infective dose; dpi, day postinfection.
