Table 2.

Amino acid sequences of the KNU18–91 isolate at the cleavage site and RBS for the HA gene [22, 23]

Strain	HA cleavage site	Conserved amino acids in RBSc					Reference
	amino acids 339–349	150	202	206	237	238		240
Low Pathogenicity
KNU18–91	PQRETRa/GLF	A	E	L	G	Q	G	New isolate
SBD/Korea/KNU SYG06/06 (H5N3)	PQRETR/GLF	A	E	L	G	Q	G
A/aquatic bird/South Korea/sw007/2015(H5N3)	PQRETR/GLF	A	E	L	G	Q	G
Aquatic bird/Korea/w54/05 (H5N2)	PQRETR/GLF	A	E	L	G	Q	G	[22]
Mallard/Italy/36/2002 (H5N3)	PQRETR/GLF	A	E	L	G	Q	G
Mallard/JiangXi/13487/05 (H5N3)	PQRETR/GLF	A	E	L	G	Q	G
A/duck/Jiangsu/S1665/2015 H5N3	PQRETR/GLF	A	E	L	G	Q	A
A/wild bird/Eastern China/1754/2017 H5N3	PQRETR/GLF	A	E	L	G	Q	G
A/wild bird/Eastern China/1758/2017 H5N3	PQRETR/GLF	A	E	L	G	Q	G
A/wild bird/Eastern China/1759/2017 H5N3	PQRETR/GLF	A	E	L	G	Q	G	[9]
A/duck/Chongqing/S4362/2017 H5N3	PQRETR/GLF	A	E	L	G	Q	G
A/duck/Jiangsu/SE0261/2018 H5N3	PQRETR/GLF	A	E	L	G	Q	G
A/duck/Guangxi/S10712/2018 H5N3	PQRETR/GLF	A	E	L	G	Q	G
High pathogenicity
A/goose/Taiwan/01042/2015(H5N3)	RERRRKRb/GLF	A	E	L	G	Q	G
A/goose/Taiwan/01004/2015(H5N2)	RERRRKR/GLF	A	E	L	G	Q	G	[23]
A/goose/Taiwan/01003/2015(H5N8)	RERRRKR/GLF	A	E	L	G	Q	G

RBS, receptor-binding site; HA, hemagglutinin.

^aMonobasic cleavage site.

^bPolybasic cleavage site.

^cReceptor binding site.