Skip to main content
. Author manuscript; available in PMC: 2023 Mar 1.
Published in final edited form as: Metabolism. 2022 Jan 7;128:155117. doi: 10.1016/j.metabol.2021.155117

Figure 3: Increased arginine-stimulated insulin secretion corrected for glycemia after insulin pre-exposure in healthy humans.

Figure 3:

During arginine stimulation (by intravenous bolus at time 240 minutes and continuous infusion time 260–290 minutes) the mean plasma glucose concentrations were lower following hyperinsulinemic compared with saline pre-exposure [A]. To account for potential confounding of different glucose concentrations achieved during the two study conditions, the insulin to glucose [B] and C-peptide-to-glucose [C] ratios were calculated, and found higher in response to arginine stimulation with hyperinsulinemia. The insulin secretion rate (ISR) estimated using the C-peptide deconvolution method was also higher in response to arginine bolus and infusion after insulin compared to saline pre-exposure [D]. After insulin pre-exposure there was a trend toward higher ISR in response to acute bolus arginine administration (P=0.169), and a significantly higher ISR response to arginine infusion (P<0.001). Saline clamp (○), insulin clamp (●).