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. 2022 Jan 16;6(3):243–255. doi: 10.7150/ntno.65544

Figure 2.

Figure 2

Nanoparticle Stability and Toxicity. (A) Size of empty NP and α-PD-L1 NP were tracked over time using Zetasizer Nano ZS90. (n=3 in each group). (B) Cell number of MC38 were counted 26hours after culture with 10µg/ml α-PD-L1 mAb, α-PD-L1 NP, or empty NP. (C) Body weight of healthy mice that received control IgG, α-PD-L1 mAb, or α-PD-L1 NP were recorded every 3-4 days (n=3; 200µg/mice, 3 injections over 9 days; left). 20% weight loss is a criterion for euthanasia (dotted line above and below). Spleen weight of healthy mice that received either PBS or empty NP was measured at 4 weeks post treatment (n=3; right).