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. 2022 Jan 24;12(4):1756–1768. doi: 10.7150/thno.68756

Figure 6.

Figure 6

Chemo-immunotherapy inhibited metastasis. (A) Treatment schedule in 4T1 orthotopic mammary tumor model. Mice were randomly divided into four groups (n = 5): (1) PBS, (2) anti-PD-1, (3) ID@M-N+L, (4) ID@M-N+L+anti-PD-1. (B) Tumor growth curves, (C) tumor weight, (D) Survival time, and (E) number of pulmonary metastatic nodules in each group. (F) CTLs infiltration and (G) ratio of CD8+/CD4+ T cells in tumor tissue after 4 days of treatment. (H) TNF-α, (I) IFN-γ, (J) IL-6 levels in serum. All data are mean ± SD (n = 5). *, # P < 0.05 compared with the ID@M-N + L (#) and PBS (*).