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. Author manuscript; available in PMC: 2022 Feb 11.
Published in final edited form as: Circulation. 2018 Nov 27;138(22):2469–2481. doi: 10.1161/CIRCULATIONAHA.118.036063

Table 2.

Associations between genetically predicted levels of a protein and clinical diagnoses related to atherosclerotic disease.

Protein Clinical diagnosis Cases Controls CIS* Odds-ratio† 95% CI p-value
CLC1B Atherosclerosis of the extremities 2,683 24,460 Yes 1.14 (1.09–1.18) 3.0 ×10−9
MICA Occlusion/stenosis of precerebral arteries 3,784 27,696 Yes 1.08 (1.04–1.11) 7.9 ×10−5
PCSK7 Atherosclerosis of the extremities 487 26108 Yes 1.23 (1.12–1.36) 1.8 ×10−5
PDGFR-β Acute cerebrovascular disease 1,184 28,518 Yes 0.88 (0.83–0.94) 4.6 ×10−5
sE-Selectin Occlusion of cerebral arteries 1,772 29,416 No 0.91 (0.87–0.95) 8.0 ×10−5
VEGF-sR2 Occlusion of cerebral arteries 1,772 29,416 No 0.91 (0.87–0.95) 7.5 ×10−5

Footnotes:

*

Indicates whether the association was significant (p<0.01) when analyses were limited to SNPs located within 1 Mb of the gene locus.

†

Based on logistic regression analyses adjusting for birth year, gender, eMERGE site, genotyping platform and 3 principal components.