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Immunohistochemistry for 4-HNE protein adducts in the lungs of a COVID-19 patient with pneumonia and DAD. There is a marked immunohistochemical positivity for 4-HNE present in the vessel wall (blue arrow), edematous fluid (asterisks), and interstitial stroma (red arrows). Some PMNs within the blood vessel and inflammatory cells in lung tissue are also positive (black arrows), while the majority are negative for 4-HNE, contrast-stained blue by hematoxylin (yellow arrows) (DAB, 600×).
