Table 2.
Most relevant pathways altered in 15-day-old DJ-1β mutants compared to control flies.
| Pathway | Number of Differential Metabolites/Totals | Raw p-Value |
p-Value FDR Corrected |
Impact |
|---|---|---|---|---|
| Glyoxylate and dicarboxylate metabolism | 6/24 | 1.03 × 10−11 | 3.50 × 10−10 | 0.17 |
| beta-Alanine metabolism | 2/14 | 8.98 × 10−11 | 1.53 × 10−9 | 0.28 |
| Glycerophospholipid metabolism | 2/32 | 4.74 × 10−10 | 4.15 × 10−9 | 0.11 |
| Citrate cycle (TCA cycle) | 5/20 | 4.89 × 10−10 | 4.15 × 10−9 | 0.24 |
| Taurine and hypotaurine metabolism | 1/7 | 5.08 × 10−9 | 2.88 × 10−8 | 0.20 |
| Histidine metabolism | 2/9 | 2.79 × 10−8 | 1.36 × 10−7 | 0.40 |
| Pyruvate metabolism | 4/22 | 1.88 × 10−7 | 7.09 × 10−7 | 0.28 |
| Alanine, aspartate and glutamate metabolism | 6/23 | 1.33 × 10−5 | 2.66 × 10−5 | 0.19 |
| Glycine, serine and threonine metabolism | 3/30 | 3.65 × 10−5 | 6.20 × 10−5 | 0.33 |
| Arginine biosynthesis | 3/12 | 2.89 × 10−4 | 4.67 × 10−4 | 0.40 |
| Nicotinate and nicotinemide metabolism | 1/9 | 4.03 × 10−4 | 6.23 × 10−4 | 0.37 |
| Tyrosine metabolism | 2/33 | 2.52 × 10−3 | 3.72 × 10−3 | 0.04 |
| Purine metabolism | 3/63 | 7.64 × 10−3 | 9.98 × 10−3 | 0.02 |
| Glycolysis/Gluconeogenesis | 4/26 | 1.76 × 10−2 | 2.21 × 10−2 | 0.13 |
This table presents the most significant pathways (p-value FDR corrected < 0.05) with a considerable impact power, which were altered in 15-day-old DJ-1β mutant compared to control flies. In particular, the number of differential metabolites/total indicates matched number of metabolites in the total number of compounds in the pathway; raw p-value is the original p-value calculated from the enrichment analysis; p-value FDR corrected is the p-value adjusted using False Discovery Rate; the impact is the pathway impact value calculated from pathway topology analysis.