Table 1.
Occurrence of IspH in the bacteria classified as priority by the WHO.
| Priority | Bacteria | IspH |
|---|---|---|
| critical | Acinetobacter baumannii, carbapenem-resistant | + |
| Pseudomonas aeruginosa, carbapenem-resistant | + | |
| Enterobacteriaceae, carbapenem-resistant, ESBL-producing | + | |
| high | Enterococcus faecium, vancomycin-resistant | − a |
| Staphylococcus aureus, methicillin-resistant, vancomycin-intermediate and resistant | − | |
| Helicobacter pylori, clarithromycin-resistant | + | |
| Campylobacter spp., fluoroquinolone-resistant | + | |
| Salmonellae, fluoroquinolone-resistant | + | |
| Neisseria gonorrhoeae, cephalosporin-resistant, fluoroquinolone-resistant | + | |
| medium | Streptococcus pneumoniae, penicillin-non-susceptible | − |
| Haemophilus influenzae, ampicillin-resistant | + | |
| Shigella spp., fluoroquinolone-resistant | + |
a partial IspH protein with incomplete catalytic site; rely on MVA pathway [14].