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Elsevier - PMC COVID-19 Collection logoLink to Elsevier - PMC COVID-19 Collection
. 2022 Feb 17;198:65–84. doi: 10.1016/j.matcom.2022.02.009

Mathematical analysis of an extended SEIR model of COVID-19 using the ABC-fractional operator

Wutiphol Sintunavarat 1,1, Ali Turab 1,⁎,1
PMCID: PMC8851883  PMID: 35194306

Abstract

This paper aims to suggest a time-fractional SPEPIPAIPSPHPRP model of the COVID-19 pandemic disease in the sense of the Atangana–Baleanu–Caputo operator. The proposed model consists of six compartments: susceptible, exposed, infected (asymptomatic and symptomatic), hospitalized and recovered population. We prove the existence and uniqueness of solutions to the proposed model via fixed point theory. Furthermore, a stability analysis in the context of Ulam–Hyers and the generalized Ulam–Hyers criterion is also discussed. For the approximate solution of the suggested model, we use a well-known and efficient numerical technique, namely the Toufik–Atangana numerical scheme, which validates the importance of arbitrary order derivative ϑ and our obtained theoretical results. Finally, a concise analysis of the simulation is proposed to explain the spread of the infection in society.

Keywords: Fractional calculus, COVID-19, Banach contraction mapping principle, Schauder fixed point theorem

1. Introduction

Infectious diseases have been a constant threat to humanity. This threat has increased in recent decades due to the emergence and re-emergence of several lethal infectious diseases. Mathematical analysis and modeling enable officials to comprehend and forecast the dynamics of an infectious disease under several distinct circumstances (see [7], [11], [17], [26], [45]).

Fractional calculus is used to examine the effect of memory on computer models, resulting in more accurate results. Due to hereditary characteristics and the notion of memory, fractional calculus is more adaptable than classical calculus. Caputo [28], Liouville–Caputo [13], and Caputo and Fabrizio [12] all put out many ideas on fractional-order operators, and these ideas are highly useful in constructing models for a variety of real-world applications (see [1], [3], [4], [5], [18], [20], [24], [31], [32], [33], [38] and the references therein). Furthermore, when using numerical approaches and comparing the relationships between different situations, the above-mentioned derivatives have been shown to be highly effective. Many studies have shown that using fractional-order derivatives produces better results in obtaining actual data for various models (see [22], [34], [37], [39] and the references therein). Atangana and Baleanu [9] first implemented a new fractional-order derivative in 2016. It was based on the principle of a generalized Mittag-Leffler function in the role of a non-singular and non-local kernel. The newly formulated Atangana–Baleanu (AB) derivative produces better results in many real-world problems (see [10], [14], [29]).

Coronavirus infection (COVID-19) is a contagious disease that began in December 2019 in China and has since spread worldwide (see [42], [43]). The World Health Organization (WHO) named this epidemic on 11 February 2020 as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (see [15], [27]). The WHO announced it as a Public Health Disaster of International Significance on 30 January 2020 (see [44]). As of 11 March 2020, the disease was recorded in more than 118,000 individuals worldwide in 114 nations. Among them, more than 90 percent of infections occurred in only four countries (two of these — China and the Republic of Korea-have dramatically reduced epidemics), and the WHO proclaimed it to be a pandemic, the first triggered by a coronavirus (see [2]). Officially confirmed incidents and deaths on 1st April 2020 were 872,481 and 43,275, respectively, and there was no antidote expressly developed for this strain, with proven efficacy.

The literature includes several mathematical models that aim to explain the dynamics of COVID-19’s development. Three phenomenological models are provided in [30], which have been validated for outbreaks of other diseases other than COVID-19, seeking to produce and test short-term estimates of the total recorded events. Other research (see, e.g., [21]) suggests minor modifications of the SEIR form, including stochastic components.

COVID-19 is a disease triggered by a modern virus that creates a worldwide emergency and requires a model that considers its unique characteristics. In specific, creating a model that integrates the following would be appropriate:

  • the impact of undetected infected individuals (see [25]) indicates that COVID-19 is based on the ratio of cases observed overestimated gross infected people;

  • the impact of various sanitary and contagious factors on hospitalized individuals (differentiating those with moderate and extreme conditions to survive from others that would ultimately die);

  • calculating bed demands in hospitals (one of the main issues confronting policy-makers tackling COVID-19).

The main objective of this research is to study an epidemic fractional-order SPEPIPAIPSPHPRP model, which investigates the significance of COVID-19 spread in society. The paper is organized in the following sections. The derivation of the proposed compartmental model is outlined in Section 2. In Section 3, we presented some basic results related to fractional calculus. The existence and uniqueness of solutions to the proposed COVID-19 fractional-order model are given in Section 4. Section 5 explores some mathematical properties of the fractional model in detail. The proofs of the positivity and boundedness of solutions are done in Section 5. The stability analysis of the proposed model in the form of Ulam–Hyers and generalized Ulam–Hyers has been discussed in Section 6. In the end, we have used a Toufik–Atangana numerical scheme for the approximate solution of the proposed fractional model.

2. Formulation of the model

The model described here is an update of the SEIR model having two additional compartments. We propose an SPEPIPAIPSPHPRP constituent model, which contains the susceptible, exposed, infected (asymptomatic and symptomatic), hospitalized, and recovered population (see Fig. 1).

Fig. 1.

Fig. 1

Flowchart of (SPEPIPAIPSPHPRP) model.

Because of this operator’s performance in simulating epidemic diseases and inspired by the practical applications of certain fractional operators in modeling such problems, in this paper, we are investigating the dynamics of the novel coronavirus model in the context of the nonlinear differential equation method involving the Atangana–Baleanu–Caputo (shortly, ABC) fractional derivative. Here, we give the following fractional system:

ABCD0ϑSP(t)=ΠSP(t)NξAϑIPA(t)+ξSPϑIPSP(t)dϑSP(t),ABCD0ϑEP(t)=SP(t)NξAϑIPA(t)+ξSPϑIPSP(t)λϑ+κ1ϑEP(t),ABCD0ϑIPA(t)=χλϑEP(t)γ1ϑ+κ2ϑIPA(t),ABCD0ϑIPS(t)=1χλϑEP(t)γ2ϑ+κ3ϑIPS(t),ABCD0ϑHP(t)=γ1ϑIPA(t)+γ2ϑIPS(t)ϑ+κ4ϑHP(t),ABCD0ϑRP(t)=ϑHP(t)dϑRP(t), (2.1)

with the initial conditions

SP(0)=SP0,EP(0)=EP0,IPA(0)=IP0A,IPSP(0)=IP0SP,HP(0)=HP0,RP(0)=RP0, (2.2)

where Πn×N,N is the total number of individuals and n is the birth rate, ABCD0ϑ denotes the ABC fractional derivative of order ϑ[0,1) and all other parameters are described in Table 1. It is important to note that the model’s parameters are non-negative and having dimensions 1timeϑ.

Table 1.

Description of the parameters.

Parameter Description
dϑ Death rate of individuals
ξAϑ,ξSPϑ Transmission rates to the susceptible population from the asymptomatic and symptomatic populations, respectively
1λϑ Incubation period of an exposed individual
χ,1χ Fraction of the exposed population that becomes asymptomatic after the incubation period and the remaining of the population are symptomatic, respectively
γ1ϑ,γ2ϑ Infectious rates of an asymptomatic and a symptomatic individual, respectively
ϑ Recovery rate through hospitalization
κ1ϑ,κ2ϑ,κ3ϑ,κ4ϑ Mortality rates of the exposed, asymptomatic, symptomatic and hospitalized populations, respectively

The total population at time t is N which is further divided into SP(t),EP(t),IPA(t), IPSP(t),HP(t) and RP(t). The key assumptions are as follows:

  • 1.

    natural mortality and birth rates are same;

  • 2.

    the natural causes of death account for fatalities are presented in compartments SP and RP;

  • 3.

    the model’s death population is made up of individuals who died as a result of exposure κ1ϑEP(t), during infectious period (κ2ϑIPA(t) and κ3ϑIPSP(t)) and hospitalization κ4ϑHP(t);

  • 4.

    the total number of dead population from each compartment can be calculated by νNdϑSP+dϑRP+κ1ϑEP+κ2ϑIPA+κ3ϑIPSP+κ4ϑHP;

  • 5.

    other natural disasters have had a minimal effect on the population; therefore, we are neglecting them.

3. Auxiliary results

The following concepts and proven results would be needed in the sequel.

Definition 3.1 [35]

Let p[1,) and O be an open subset of R, the Sobolev space Hp(O) is defined by

Hp(O)={ΨL2(O):DμΨL2(O), for all |μ|p}.

Based on the above definition, Atangana and Baleanu [9] gave the following definition of the Atangana–Baleanu fractional derivative in Caputo sense.

Definition 3.2 [9]

Let ΨH1(a,b), where a,bR with a<b, and ϑ[0,1). The Atangana and Baleanu fractional derivative in Caputo sense (shorten, ABC) are defined as follows:

ABCDaϑΨ(t)=ω(ϑ)1ϑatddςΨ(ς)Eϑϑ1ϑ(tς)ϑdς, (3.1)

where ω is the normalization function defined by ω(ϑ)=ϑ2ϑ, for all 0ϑ<1. Also, Eϑ stands for the Mittag-Leffler function which is a generalization of the exponential function (see [16], [23], [28]).

Remark 3.3

If we replace Eϑϑ1ϑ(tς)ϑ by E1=expϑ1ϑ(tς), then we get the so-called Caputo–Fabrizio differential operator. Further, it is to be noted that

ABCD0ϑ(Constant)=0. (3.2)

Definition 3.4 [9]

The Laplace transform of (3.1) is defined as follows:

LABCDaϑΨ(t)(s)=ω(ϑ)1ϑLatΨ(ς)Eϑϑ(tς)ϑ1ϑdς=ω(ϑ)1ϑsϑLΨ(t)(s)sϑ1Ψ(0)sϑ+ϑ1ϑ. (3.3)

Definition 3.5 [9]

Let ΨH1(a,b), where a,bR with a<b, and ϑ[0,1). The corresponding integral in ABC sense are defined as follows:

ABCIaϑΨ(t)=1ϑω(ϑ)Ψ(t)+ϑω(ϑ)Γ(ϑ)at(tς)ϑ1Ψ(ς)dς, (3.4)

where Γ is a gamma function.

Lemma 3.6

The solution of the given problem for0ϑ<1,

ABCD0ϑΨ(t)=σ(t),t[0,T], Ψ(0)=Ψ0, (3.5)

whereΨ:[0,T]Ris an unknown function andΨ0 is a fixed constant, provided by

Ψ(t)=Ψ0+1ϑω(ϑ)σ(t)+ϑω(ϑ)Γ(ϑ)0t(tς)ϑ1σ(ς)dς. (3.6)

For the qualitative analysis, we define the Banach space F=Y×Y×Y×Y×Y×Y, where Y=C[0,T] with 0<T<, under the norm given for Ψ=ψ1,ψ2,ψ3,ψ4,ψ5,ψ6TF by

Ψ=ψ1,ψ2,ψ3,ψ4,ψ5,ψ6T=maxt[0,T]|ψ1(t)|+|ψ2(t)|+|ψ3(t)|+|ψ4(t)|+|ψ5(t)|+|ψ6(t)|.

Throughout this paper, for v=(v1,v2,,v6)R6, we use this notion || as the taxicab norm in R6.

4. Existence and uniqueness of a solution

We shall examine the existence and uniqueness of a solution to our main model (2.1) with the condition (2.2) in this section. Let us write the model (2.1) with the condition (2.2) as

ABCD0ϑSP(t)=Θ1SP(t),EP(t),IPA(t),IPSP(t),HP(t),RP(t),ABCD0ϑEP(t)=Θ2SP(t),EP(t),IPA(t),IPSP(t),HP(t),RP(t),ABCD0ϑIPA(t)=Θ3SP(t),EP(t),IPA(t),IPSP(t),HP(t),RP(t),ABCD0ϑIPSP(t)=Θ4SP(t),EP(t),IPA(t),IPSP(t),HP(t),RP(t),ABCD0ϑHP(t)=Θ5SP(t),EP(t),IPA(t),IPSP(t),HP(t),RP(t),ABCD0ϑRP(t)=Θ6SP(t),EP(t),IPA(t),IPSP(t),HP(t),RP(t), (4.1)

where

Θ1SP(t),EP(t),IPA(t),IPSP(t),HP(t),RP(t)=ΠSP(t)NξAϑIPA(t)+ξSPϑIPSP(t)dϑSP(t),Θ2SP(t),EP(t),IPA(t),IPSP(t),HP(t),RP(t)=SP(t)NξAϑIPA(t)+ξSPϑIPSP(t)λϑ+κ1ϑEP(t),Θ3SP(t),EP(t),IPA(t),IPSP(t),HP(t),RP(t)=χλϑEP(t)γ1ϑ+κ2ϑIPA(t),Θ4SP(t),EP(t),IPA(t),IPSP(t),HP(t),RP(t)=1χλϑEP(t)γ2ϑ+κ3ϑIPSP(t),Θ5SP(t),EP(t),IPA(t),IPSP(t),HP(t),RP(t)=γ1ϑIPA(t)+γ2ϑIPSP(t)ϑ+κ4ϑHP(t),
Θ6SP(t),EP(t),IPA(t),IPSP(t),HP(t),RP(t)=ϑHP(t)dϑRP(t) (4.2)

with the condition (2.2). By using (2.1), we transform (4.2) with (2.2) to the following system:

ABCD0ϑΨ(t)=Qt,Ψ(t),Ψ(0)=Ψ0, (4.3)

where

Ψ=SPEPIPAIPSPHPRP,ABCD0ϑΨ=ABCD0ϑSPABCD0ϑEPABCD0ϑIPAABCD0ϑIPSPABCD0ϑHPABCD0ϑRP,Ψ0=SP0EP0IP0AIP0SPHP0RP0,

and

Qt,Ψ(t)=Θ1SP(t),EP(t),IPA(t),IPSP(t),HP(t),RP(t)Θ2SP(t),EP(t),IPA(t),IPSP(t),HP(t),RP(t)Θ3SP(t),EP(t),IPA(t),IPSP(t),HP(t),RP(t)Θ4SP(t),EP(t),IPA(t),IPSP(t),HP(t),RP(t)Θ5SP(t),EP(t),IPA(t),IPSP(t),HP(t),RP(t)Θ6SP(t),EP(t),IPA(t),IPSP(t),HP(t),RP(t).

Using Lemma 3.6, the model (4.3) can be turned to the fractional integral equation in the sense of ABC fractional integral as follows:

Ψ(t)=Ψ0+1ϑω(ϑ)Qt,Ψ(t)+ϑω(ϑ)Γ(ϑ)0t(tς)ϑ1Qς,Ψ(ς)dς. (4.4)

Here we impose the following conditions:

  • (Δ1)
    there exist two constants p1>0 and p2>0 such that
    |Qt,Ψ(t)|p1Ψ+p2, (4.5)
    for all t[0,T].
  • (Δ2)
    there exists p3>0 such that
    |Qt,Ψ(t)Qt,Ψ¯(t)|p3|Ψ(t)Ψ¯(t)|, (4.6)
    for each Ψ,Ψ¯F and t[0,T].

We start with the following result.

Lemma 4.1

The operatorC :FFare defined in(4.4) is completely continuous.

Proof

First, we see that if ΨF, then ΨF. For each ΨDZ{ΨF:ΨZ}, we obtain

|Ψ(t)|Ψ0+1ϑω(ϑ)maxt[0,1]|Qt,Ψ(t)|+maxt[0,1]ϑω(ϑ)Γ(ϑ)×0t(tς)ϑ1|Qς,Ψ(ς)|dςΨ0+1ϑω(ϑ)p1Ψ+p2+ϑω(ϑ)Γ(ϑ)0t(tς)ϑ1p1Ψ+p2dςΨ0+1ϑω(ϑ)+Tϑω(ϑ)Γ(ϑ)p2+1ϑω(ϑ)+Tϑω(ϑ)Γ(ϑ)p1ΨΨ0+Λp1Ψ+p2<+,

where Λ1ϑω(ϑ)+Tϑω(ϑ)Γ(ϑ). This implies that

Ψ+.

Hence,  is uniformly bounded on DZ.

Next, we have to prove that the operator  is equicontinuous. For this, let ΨDZ and t1,t2[0,T] such that t1<t2. Then

|Ψ(t2)Ψ(t1)|ϑω(ϑ)Γ(ϑ)t1t2(t2ς)ϑ1|Qς,Ψ(ς)|dς+ϑω(ϑ)Γ(ϑ)0t1(t2ς)ϑ1(t1ς)ϑ1|Qς,Ψ(ς)|dς
p1Z+p2ω(ϑ)Γ(ϑ)2(t2t1)ϑ+(t2ϑt1ϑ).

Due to the fact that t1t2, the right hand side of the preceding inequality approaches to zero. As a result of the Arzelá–Ascoli theorem, is compact and therefore completely continuous. □

Theorem 4.2

Assume thatQ:[0,T]×R6Ris continuous and(Δ1) is satisfied. Then the integral Eq. (4.4) which is equivalent to the proposed COVID-19 model (2.1) (2.2) has at least one solution.

Proof

Consider S{ΨF:Ψ=δ(Ψ)(t),0<δ<1}. From Lemma 4.1, it is clear that the operator C : SF as given in (4.9) is completely continuous. From (Δ1), for any ΨS, we obtain

|Ψ(t)|=|δ(Ψ)(t)|Ψ0+1ϑω(ϑ)|Qt,Ψ(t)|+ϑω(ϑ)Γ(ϑ)0t(tς)ϑ1|Qς,Ψ(ς)|dςΨ0+1ϑω(ϑ)p1Ψ+p2+ϑω(ϑ)Γ(ϑ)0t(tς)ϑ1p1Ψ+p2dςΨ0+Λp2+p1Ψ<+,

where Λ1ϑω(ϑ)+Tϑω(ϑ)Γ(ϑ). This implies that

Ψ+.

As a result, S is bounded. Hence, the operator has at least one fixed point, which happens to be the solution of the COVID-19 model (2.1)(2.2). □

Theorem 4.3

Suppose thatΨF and Ψ maps a bounded subset of [0,T] into relatively compact subset of R6 . Then the integral Eq. (4.4) which is equivalent to the proposed model (2.1) with the condition (2.2) has a unique solution provided that Λ~1,Λp3<1 , where

Λ1ϑω(ϑ)+Tϑω(ϑ)Γ(ϑ), (4.7)

and

Λ~11ϑω(ϑ)+Tϑω(ϑ)Γ(ϑ)p1. (4.8)

Proof

Let the operator C : FF defined for each ΨF by

Ψ(t)=Ψ0+1ϑω(ϑ)Qt,Ψ(t)+ϑω(ϑ)Γ(ϑ)0t(tς)ϑ1Qς,Ψ(ς)dς, (4.9)

for all t[0,T]. It can be seen that the operator  is well defined and the unique solution of (4.9) is just the fixed point of . Here, we consider DZ={ΨF:ΨZ} as a closed and convex set with ZΛ~21Λ~1, where

Λ~2Ψ0+1ϑω(ϑ)+Tϑω(ϑ)Γ(ϑ)p2. (4.10)

Thus, it is enough to show that DZDZ. Now, for any ΨDZ, it yields

|Ψ(t)|Ψ0+1ϑω(ϑ)|Qt,Ψ(t)|+ϑω(ϑ)Γ(ϑ)0t(tς)ϑ1|Qς,Ψ(ς)|dςΨ0+1ϑω(ϑ)p1Ψ+p2+ϑω(ϑ)Γ(ϑ)0t(tς)ϑ1p1Ψ+p2dςΨ0+1ϑω(ϑ)+Tϑω(ϑ)Γ(ϑ)p2+1ϑω(ϑ)+Tϑω(ϑ)Γ(ϑ)p1Z=Λ~2+Λ~1ZZ.

Now, let Ψ1,Ψ2F and t[0,T]. Then, we obtain

|Ψ1(t)Ψ2(t)|1ϑω(ϑ)|Qς,Ψ1(ς)Qς,Ψ2(ς)|+ϑω(ϑ)Γ(ϑ)0t(tς)ϑ1|Qς,Ψ1(ς)Qς,Ψ2(ς)|dς1ϑω(ϑ)+Tϑω(ϑ)Γ(ϑ)p3Ψ1Ψ2=Λp3Ψ1Ψ2.

This implies that

Ψ1Ψ2Λp3Ψ1Ψ2.

As Λp3<1, therefore is a Banach contraction mapping. Hence, the integral Eq. (4.4) has a unique solution. Consequently, the proposed COVID-19 model (2.1)(2.2) has a unique solution. □

5. Properties of the model

Here, we discuss some critical aspects of the model (2.1) or, more precisely, the system (4.3), including the boundedness and positivity of the solutions for t0.

5.1. Invariant region

The boundary of solutions for the nonlinear system (2.1) with non-negative initial conditions is determined in this subsection. Our major goal is to prove that the feasible region produced in R+6 is positively invariant with respect to the fractional model (2.1).

Theorem 5.1

The feasible region of the proposed fractional model (2.1) is given by

Ω(SP,EP,IPA,IPSP,HP,RP)R+6:0NΠν;SP,EP,IPA,IPSP,HP,RP0 (5.1)

The existence and uniqueness of the solution of model (2.1) have already been shown in the preceding section; all that remains is to demonstrate that the set Ω is positively invariant with respect to the condition (2.2). For the proof of Theorem 5.1, the following theorem will be utilized.

Theorem 5.2

The solutions of the system (2.1) are bounded.

Proof

To obtain the fractional derivative of total population, we add all the relations in system (2.1). So

ABCD0ϑN(t)=ABCD0ϑSP(t)+ABCD0ϑEP(t)+ABCD0ϑIPA(t)+ABCD0ϑIPSP(t)+ABCD0ϑHP(t)+ABCD0ϑRP=ΠdϑSP(t)dϑRP(t)κ1ϑEP(t)κ2ϑIPA(t)κ3ϑIPSP(t)κ4ϑHP(t)=ΠνN(t). (5.2)

By applying the Laplace transform on both sides of above inequality, we obtain

LABCD0ϑN(t)(s)=ΠsνLN(t)(s)

and then

ω(ϑ)sϑLN(t)(s)ϑ+(1ϑ)sϑ+νLN(t)(s)=Πsϑ(ϑ+1)+ω(ϑ)N(0)sϑ1ϑ+(1ϑ)sϑ,

where N(0) represents the initial value of the total population and ω is the normalization function defined in Definition 3.2. This implies that

LN(t)(s)=Π(1ϑ)sϑ+ϑsϑ(ϑ+1)+ω(ϑ)sϑ1N(0)νϑ+(1ϑ)sϑϑ+ω(ϑ)sϑ.

Now, by applying the inverse Laplace transform, we have

N(t)=Πϑtϑ(1ϑ)ν+ω(ϑ)Eϑ,ϑ+1tϑ+Π(1ϑ)(1ϑ)ν+ω(ϑ)+ω(ϑ)N(0)ω(ϑ)+(1ϑ)νEϑ,1tϑ, (5.3)

where =ϑwω(ϑ)+(1ϑ)ν, and Ea,b is the Mittag-Leffler function with two parameters a>0 and b>0 may be defined by the following series

Ea,b(ħ)=n=0ħnΓ(an+b),

whose Laplace transform is

Ltb1Ea,b±Λta=sabsaΛ,

provided that s>Λ1/a. For a,b>0, the Mittag-Leffler function satisfies

Ea,b(ħ)=1ħEa,ba(ħ)1Γ(ba),

and for the case a=ϑ,b=ϑ+1 and ħ=tϑ, we have

Eϑ,ϑ+1tϑ=1tϑ1Eϑ,1tϑ. (5.4)

From [9], it is clear that the Mittag-Leffler function is bounded for all t>0 and possess an asymptotic behavior. Therefore, from (5.2), (5.3), we can say that N(t)Πν as t. Thus, N(t) and all other variables of the model (2.1) are bounded in a region Ω.

The solution remains x=0 for all t>0 if x0=0. Furthermore, for any non-negative set of initial conditions in Ω, every solution of model (2.1) in

R+6=yR6:y0,y(t)=SP,EP,IPA,IPSP,HP,RPT,

approaches asymptotically in finite time t, enters and remains in Ω. Thus, the closed set Ω is positively invariant for our system (2.1). □

5.2. Positivity of solutions

In this subsection, we will show that for all t0, the state variables SP,EP,IPA,IPSP,HP and RP are positive. This characteristic is essential in order to demonstrate that our model is physically feasible.

Theorem 5.3

The solution space SP,EP,IPA,IPSP,HP,RP of the system (2.1) will remain positive forever with any non-negative initial data.

Proof

First equation of the model (2.1) is rearranged to give

ABCD0ϑSP(t)1NξAϑIPA(t)+ξSPϑIPSP(t)+dϑSP(t).

As all the solutions are bounded, therefore, we let IPA(t)N and IPSP(t)N are bounded by ρ1 and ρ2 respectively. Then,

ABCD0ϑSP(t)qSP(t), (5.5)

where qξAϑρ1+ξSPϑρ2+dϑ is a constant. Applying the Laplace transform on both sides of (5.5), we obtain

ω(ϑ)sϑϑ+(1ϑ)sϑLSP(t)(s)ω(ϑ)sϑϑ+(1ϑ)sϑSP(0)qLSP(t)(s),

and

LSP(t)(s)ω(ϑ)sϑ1SP(0)ω(ϑ)+q(1ϑ)sϑ1sϑ+qϑω(ϑ)+q(1ϑ).

Now, by applying the inverse Laplace transform, we have

SP(t)ω(ϑ)sϑ1SP(0)ω(ϑ)+q(1ϑ)Eϑ,1tϑqϑω(ϑ)+q(1ϑ). (5.6)

Because both of the values on the right-hand side of (5.6) are positive. Therefore, for every t0, the solution SP(t) also remains positive. Likewise, for every t0 corresponding to any non-negative initial data, we can simply argue that EP>0,IPA>0,IPSP>0,HP>0,RP>0. As a result, the solutions in R+6 will always be positive. □

5.3. Equilibrium points

Here, by solving the following system yields the equilibrium points of the suggested fractional model (2.1):

ABCD0ϑSP=ABCD0ϑEP=ABCD0ϑIPA=ABCD0ϑIPSP=ABCD0ϑHP=ABCD0ϑRP=0.

The proposed model (2.1) has a unique non-negative Corona free equilibrium at the point after simple computations given by

EP0=SP0,EP0,IP0A,IP0SP,HP0,RP0=Πν,0,0,0,0,0,

and a unique non-negative Corona present equilibrium at the point given by

EP1=SP1,EP1,IP1A,IP1SP,HP1,RP1,

in the epidemiological region Ω, where

SP1=SP0RP0>0,
EP1=RP01RP0dϑSP0RP0λϑ+κ1ϑ>0,
IP1A=RP01RP0dϑχλϑSP0RP0λϑ+κ1ϑγ1ϑ+κ2ϑ>0,
IP1SP=RP01RP0dϑ(1χ)λϑSP0RP0λϑ+κ1ϑγ2ϑ+κ3ϑ>0,
HP1=RP01RP0dϑλϑSP0RP0λϑ+κ1ϑϑϑ+κ4ϑ(1χ)γ2ϑγ2ϑ+κ3ϑ+χ>0,
RP1=RP01RP0dϑϑλϑSP0RP0λϑ+κ1ϑϑϑ+κ4ϑ(1χ)γ2ϑγ2ϑ+κ3ϑ+χ>0.

5.4. Threshold parameter R0

The value of the threshold parameter, commonly represented by R0, can be used to define the dynamics of mathematical models. Any infectious disease spreads when an infected individual comes into contact with a group of entirely susceptible persons. As a result, at the time t0, a threshold parameter refers to the total number of new infections created by an infected individual. It secretly predicts a model’s dynamical behavior, indicating that it gives more excellent knowledge regarding the disease’s future spread or containment.

The value of the threshold parameter in model (2.1) is determined using the conventional next generation matrix technique. If v=v1,v2,v3,v4=EP,IPA,IPSP,HPTR+4, then the model (2.1) can be written as

ABCD0ϑvi=Fi(v)Gi(v),i=1(1)4,

where Fi(v) represents the rate of appearance of new infections in compartment i and Gi(v) denotes the rate of transfer of infections to and from compartment i.

Now, by taking the Jacobian of the matrices at point EP0, we have

F=F1EPF1IPAF1IPSPF1HPF2EPF2IPAF2IPSPF2HPF3EPF3IPAF3IPSPF3HPF4EPF4IPAF4IPSPF4HP=0ξAϑξSPϑ0000000000000,
G=G1EPG1IPAG1IPSPG1HPG2EPG2IPAG2IPSPG2HPG3EPG3IPAG3IPSPG3HPG4EPG4IPAG4IPSPG4HP=λϑ+κ1ϑ000λϑχγ1ϑ+κ2ϑ00λϑ(1χ)0γ2ϑ+κ3ϑ00γ1ϑγ2ϑϑ+κ4ϑ.

The maximum absolute eigenvalue of the positive matrix FG1 is the value of R0 for the model (2.1). That is,

R0=χξAϑγ2ϑ+κ3ϑ+(1χ)ξSPϑγ1ϑ+κ2ϑλϑλϑ+κ1ϑγ1ϑ+κ2ϑγ2ϑ+κ3ϑ.

5.5. Strength number A0

The strength number is the expansion of the reproduction number. Without a doubt, the reproduction rate is critical in the study of epidemiology when it comes to the spread and extinction of diseases. The epidemiologist uses a variety of strategies to get such numbers (i.e., violation of the reproduction number’s uniqueness and many others). The primary conclusion of this strategy depends on the prediction of the waves of the transmission of illness. The essential point is that this number is evaluated using the next-generation matrix approach by assuming coronavirus-free equilibrium in the system (2.1) and calculating the second derivative of infectious classes. As a result, the transmission and transition matrices are denoted by F and G [8], respectively, where:

F~=2F1EP22F1IPA22F1IPSP22F1HP22F2EP22F2IPA22F2IPSP22F2HP22F3EP22F32IPA22F3IPSP22F3HP22F4EP22F42IPA22F42IPSP22F4HP2=0ξAϑN2ξSPϑN20000000000000.

Then

DetF~G1θI4=0.

Hence, the strength number A0 is

A0=λϑN2χξAϑγ2ϑ+κ3ϑ+(1χ)ξSPϑγ1ϑ+κ2ϑλϑ+κ1ϑγ1ϑ+κ2ϑγ2ϑ+κ3ϑ<0.

A negative strength number indicates that the system (2.1) will have a single magnitude, either a maximum with two infection sites suggesting a single wave or a quick drop from the coronavirus-free equilibrium. As a result, the infection will grow to a minimal point with the renewal process, then stabilize or halt as requested later.

6. Stability results

The consistency of solutions has a strong emphasis on the theory of mathematical modeling. For illustration, slight variations in the model, induced by natural measurement errors in practical situations, have a minor proportional impact on the solution. The mathematical calculations that explain the system will not accurately forecast the probable result. Hence, the stability of the suggested mathematical model (2.1) with ((2.2) ) must be discussed here. For the detail of the Ulam–Hyers and generalized Ulam–Hyers stability, we refer [6], [19], [40], [41].

The definitions that follow are required in the upcoming results. Let ε>0 and consider the following inequality:

|ABCD0ϑΨ~(t)Qt,Ψ~(t)|ε,t[0,T], (6.1)

where ε=maxεjT, j=1,2,,6.

Definition 6.1

The proposed problem (3.5), which is equivalent to model (2.1)(2.2), is Ulam–Hyers stable if there exists Ξ>0 such that, for every ε>0 and for each solution Ψ~F satisfying inequality (6.1), there exists a solution ΨF of problem (4.3) with the initial condition Ψ~(0)=Ψ(0) such that 

|Ψ~(t)Ψ(t)|Ξε,t[0,T],

where

Ψ~=S~PE~PI~PAI~PSPH~PR~P,Ψ~0=S~P0E~P0I~P0AI~P0SPcvskip[3pt]H~P0R~P0,Ξ=maxΞ1Ξ2Ξ3Ξ4Ξ5Ξ6,ε=maxε1ε2ε3ε4ε5ε6,

and

Qt,Ψ~(t)=Θ~1S~P(t),E~P(t),I~PA(t),I~PSP(t),H~P(t),R~P(t)Θ~2S~P(t),E~P(t),I~PA(t),I~PSP(t),H~P(t),R~P(t)Θ~3S~P(t),E~P(t),I~PA(t),I~PSP(t),H~P(t),R~P(t)Θ~4S~P(t),E~P(t),I~PA(t),I~PSP(t),H~P(t),R~P(t)Θ~5S~P(t),E~P(t),I~PA(t),I~PSP(t),H~P(t),R~P(t)Θ~6S~P(t),E~P(t),I~PA(t),I~PSP(t),H~P(t),R~P(t).

Definition 6.2

Problem (4.3), which is equivalent to the model (2.1) with (2.2), is referred to as being generalized Ulam–Hyers stable if there exists a continuous function φ:R+R+ with φ(0)=0 such that for each solution Ψ~F of the inequality (6.1), there exists a solution ΨF of Problem (4.3) such that

|Ψ~(t)Ψ(t)|φε,  t[0,T],

where φ=maxφjT, j=1,2,,6.

Assumption 6.3

Consider a small perturbation hC[0,T] such that h(0)=0 with the following properties:

  • (i)

    |h(t)|ε, h=maxhjT, t[0,T] and ε>0;

  • (ii)
    for t[0,T], we have the following model
    ABCD0ϑΨ~(t)=Qt,Ψ~(t)+h(t),
    where h(t)=(h1(t),h2(t),,h6(t))T.

Lemma 6.4

The solution of the perturbed problem

ABCD0ϑΨ~(t)=Qt,Ψ~(t)+h(t),Ψ~(0)=Ψ~0, (6.2)

satisfies the given relation

|Ψ~h(t)Ψ~(t)|Λε,

whereΨ~h(t)is a solution of(6.2),Ψ~(t) satisfies (6.1) and Λ1ϑω(ϑ)+Tϑω(ϑ)Γ(ϑ) .

Proof

In view of (ii) of Assumption 6.3 and Lemma 3.6, the solution of (6.2) is given by

Ψ~h(t)=Ψ~0+1ϑω(ϑ)Qt,Ψ~(t)+ϑω(ϑ)Γ(ϑ)0t(tς)ϑ1Qt,Ψ~(ς)dς+1ϑω(ϑ)h(t)+ϑω(ϑ)Γ(ϑ)0t(tς)ϑ1hςdς.

Furthermore, we have

Ψ~(t)=Ψ~0+1ϑω(ϑ)Qt,Ψ~(t)+ϑω(ϑ)Γ(ϑ)0t(tς)ϑ1Qt,Ψ~(ς)dς.

Using (i) of Assumption 6.3, we get

|Ψ~h(t)Ψ~(t)|1ϑω(ϑ)|h(t)|+ϑω(ϑ)Γ(ϑ)0t(tς)ϑ1|hς|dς1ϑω(ϑ)+Tϑω(ϑ)Γ(ϑ)ε=Λε,

where Λ1ϑω(ϑ)+Tϑω(ϑ)Γ(ϑ).

This implies that

|Ψ~h(t)Ψ~(t)|Λε.

Hence, we get the desired result. □

Theorem 6.5

Under the assumptions of Theorem 4.3 , the model (2.1) (2.2) is Ulam–Hyers and, consequently, generalized Ulam–Hyers stable.

Proof

Suppose that Ψ~F satisfies inequality (6.1) and ΨF is a unique solution of problem (4.4) with the condition

Ψ(0)=Ψ~(0). (6.3)

Due to (6.3), we can write (4.4) as

Ψ(t)=Ψ~(0)+1ϑω(ϑ)Qt,Ψ(t)+ϑω(ϑ)Γ(ϑ)0t(tς)ϑ1Qς,Ψ(ς)dς.

Thus, by (Δ1)  and Lemma 6.4, we obtain

|Ψ~(t)Ψ(t)||Ψ~(t)Ψ~h(t)|+|Ψ~h(t)Ψ(t)|Λε+1ϑω(ϑ)|Qt,Ψ~(t)Qt,Ψ(t)|+Λε+ϑω(ϑ)Γ(ϑ)0t(tς)ϑ1|Qt,Ψ~(t)Qt,Ψ(t)|dς
2Λε+1ϑω(ϑ)+Tϑω(ϑ)Γ(ϑ)p3Ψ~Ψ=2Λε+Λp3Ψ~Ψ.

Hence,

Ψ~Ψ2Λε1Λp3.

As, Λp3<1, we obtain

Ψ~ΨΞε,

where Ξ 2Λ1Λp3. □

Remark 6.6

If we set φ(ε)=Ξε such that φ(0)=0, then from the above theorem, we conclude that the proposed model (2.1) with (2.2) is generalized Ulam–Hyers stable.

7. Numerical simulations and discussion

In this section, we need to examine the estimated solutions of the ABC fractional-order model (2.1) with (2.2). The theoretical models are then obtained by employing the current scheme. The ABC fractional derivative is utilized to develop the computational procedure for the simulation of our model (2.1).

7.1. General algorithm

In this subsection, we offer a numerical technique for analyzing and predicting the numerical stability of a Coronavirus fractional model (2.1) with (2.2) based on a recently developed Toufik–Atangana criterion [36]. We first outline the concept briefly before applying it to the fractional model (2.1) with (2.2) to get an iterative approach. The system (2.1) may be represented using the fundamental theorem of fractional calculus.

z(t)z(0)=1ϑω(ϑ)Ψ(t,z(t))+ϑω(ϑ)Γ(ϑ)0t(tς)ϑ1Ψ(ς,z(ς))dς,

At t=tn+1,n=0,1,2,,N with h=TN, we have

z(tn+1)=z(0)+1ϑω(ϑ)Ψ(tn,z(tn))+ϑω(ϑ)Γ(ϑ)j=0ntjtj+1(tn+1ς)ϑ1Ψ(ς,z(ς))dς. (7.1)

The function Ψ(ς,z(ς)) can be approximated over tj,tj+1, using the interpolation polynomial

Ψ(ς,z(ς))=Ψ(tj,z(tj))h×(ttj1)Ψ(tj1,z(tj1))h×(ttj).

By substituting this in (7.1), we obtain

z(tn+1)=z(0)+1ϑω(ϑ)Ψ(tn,z(tn))+ϑω(ϑ)Γ(ϑ)j=0nΨ(tj,z(tj))h×tjtj+1(tn+1t)ϑ1(ttj1)dtΨ(tj1,z(tj1))htjtj+1(tn+1t)ϑ1(ttj)dt.

Finally, we get the approximate solution as:

z(tn+1)=z(t0)+1ϑω(ϑ)Ψ(tn,z(tn))+ϑω(ϑ)j=0nhϑΨ(tj,z(tj))Γ(ϑ+2)×(nj+2+ϑ)(n+1j)ϑ(nj+2+2ϑ)(nj)ϑhϑΨ(tj1,z(tj1))Γ(ϑ+2)(n+1j)ϑ+1(nj+1+ϑ)(nj)ϑ.

Hence, we obtain the following recursive formula for the model equations:

SP(tn+1)=SP(t0)+1ϑω(ϑ)Ψ1(tn,z(tn))+ϑω(ϑ)j=0nhϑΨ1(tj,z(tj))Γ(ϑ+2)×(nj+2+ϑ)(n+1j)ϑ(nj+2+2ϑ)(nj)ϑhϑΨ1(tj1,z(tj1))Γ(ϑ+2)(n+1j)ϑ+1(nj+1+ϑ)(nj)ϑ,EP(tn+1)=EP(t0)+1ϑω(ϑ)Ψ2(tn,z(tn))+ϑω(ϑ)j=0nhϑΨ2(tj,z(tj))Γ(ϑ+2)×(nj+2+ϑ)(n+1j)ϑ(nj+2+2ϑ)(nj)ϑhϑΨ1(tj1,z(tj1))Γ(ϑ+2)(n+1j)ϑ+1(nj+1+ϑ)(nj)ϑ,
IPA(tn+1)=IPA(t0)+1ϑω(ϑ)Ψ3(tn,z(tn))+ϑω(ϑ)j=0nhϑΨ3(tj,z(tj))Γ(ϑ+2)×(nj+2+ϑ)(n+1j)ϑ(nj+2+2ϑ)(nj)ϑhϑΨ1(tj1,z(tj1))Γ(ϑ+2)(n+1j)ϑ+1(nj+1+ϑ)(nj)ϑ,IPSP(tn+1)=IPSP(t0)+1ϑω(ϑ)Ψ4(tn,z(tn))+ϑω(ϑ)j=0nhϑΨ4(tj,z(tj))Γ(ϑ+2)×(nj+2+ϑ)(n+1j)ϑ(nj+2+2ϑ)(nj)ϑhϑΨ1(tj1,z(tj1))Γ(ϑ+2)(n+1j)ϑ+1(nj+1+ϑ)(nj)ϑ,HP(tn+1)=HP(t0)+1ϑω(ϑ)Ψ5(tn,z(tn))+ϑω(ϑ)j=0nhϑΨ5(tj,z(tj))Γ(ϑ+2)×(nj+2+ϑ)(n+1j)ϑ(nj+2+2ϑ)(nj)ϑhϑΨ1(tj1,z(tj1))Γ(ϑ+2)(n+1j)ϑ+1(nj+1+ϑ)(nj)ϑ,RP(tn+1)=RP(t0)+1ϑω(ϑ)Ψ6(tn,z(tn))+ϑω(ϑ)j=0nhϑΨ6(tj,z(tj))Γ(ϑ+2)×(nj+2+ϑ)(n+1j)ϑ(nj+2+2ϑ)(nj)ϑhϑΨ1(tj1,z(tj1))Γ(ϑ+2)(n+1j)ϑ+1(nj+1+ϑ)(nj)ϑ. (7.2)

7.2. Results and discussion

This portion includes a computational simulation of the transmission dynamics of COVID-19 in society. To this end, the initial conditions are posited as SP(0)=600, IPA(0)=90,andIPSP(0)=40. Here, for the model’s parameters, we choose ξAϑ=1×1010,ξSPϑ=1.2312,λϑ=9.9618×103,κ1ϑ=3.3491×103,κ2ϑ=1×1010,κ3ϑ=3.0859×104,κ4ϑ=2.1222×105,χ=1.5683×101,γ1ϑ=2.6628×102,γ2ϑ=1,ϑ=6.170×103.

In the following Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6, Fig. 7, by using a MATLAB package, we create an algorithm to simulate the effects of different parameters corresponding to various fractional values of ϑ. We presented numerical data of 90 days. As you can see in Fig. 2, Fig. 3, Fig. 4, Fig. 5, Fig. 6, Fig. 7, the parameters have different impacts but demonstrate the same behavior in different proportions of ϑ. Fig. 2, Fig. 3 indicate that over time t, SP(t), and EP(t) (increase and decrease) hit the equilibrium point. It means the susceptible individuals will expand over time, while the exposed population will decline. It is apparent from Fig. 4, Fig. 5 that, with time, the affected community (asymptomatic IPA(t) and symptomatic IPSP(t)) hits their stable points. As COVID-19 infection cases initially rose, the amount of hospitalized patients HP(t) was higher (as seen in Fig. 6), although it would decrease with time. Also, the number of COVID-19 contaminated classes decreases over time; therefore, the recovered class RP(t) eventually decreases (see Fig. 7).

Fig. 2.

Fig. 2

The graph illustrating the approximate solution for the susceptible class (SP) at different fractional values of ϑ.

Fig. 3.

Fig. 3

The graph illustrating the approximate solution for the exposed class (EP) at different fractional values of ϑ.

Fig. 4.

Fig. 4

The graph illustrating the approximate solution for the infected asymptomatic class (IPA) at different fractional values of ϑ.

Fig. 5.

Fig. 5

The graph illustrating the approximate solution for the infected symptomatic class (IPSP) at different fractional values of ϑ.

Fig. 6.

Fig. 6

The graph illustrating the approximate solution for the hospitalized class (HP) at different fractional values of ϑ.

Fig. 7.

Fig. 7

The graph illustrating the approximate solution for the recovered class (RP) at different fractional values of ϑ.

8. Conclusion

In this work, we developed a fractional-order SPEPIPAIPSPHPRP model to examine the dynamics of a new Coronavirus infection. We employed the Atangana–Baleanu derivative operator with the generalized Mittag-Leffler function to formulate the suggested fractional model. Due to its non-local and non-singular kernel, the Atangana–Baleanu derivative operator was selected. Our study’s objective was to concentrate on an SPEPIPAIPSPHPRP model that accurately depicted the predominant properties of the Coronavirus. The fixed point theorems were used to verify the existence and uniqueness of the solution to the suggested fractional model. The basic reproduction number and strength number were calculated theoretically and numerically to account for the model’s dynamical behavior. Also, we developed some results about the qualitative theory and Ulam–Hyers stability analysis. Additionally, we calculated numerical solutions for the given model using an efficient method. Graphic representations had created to verify the dynamic behavior of the solution using Matlab. The results collected are critical in explaining the present dynamics of the COVID-19 epidemic. Moreover, it can be seen that the fractional calculus can explain the population’s dynamics more concisely. The studies reported may be more efficient with the current outbreak and use preventive measures to mitigate infection. The suggested framework may be utilized in the future to explore other nonlinear fractional differential problems using the ABC fractional derivative.

Declaration of Competing Interest

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Acknowledgment

This project is funded by National Research Council of Thailand (NRCT) N41A640092.

Availability of data and materials

Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.

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Associated Data

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Data Availability Statement

Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.


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