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. 2022 Feb 11;65(5):1040–1042. doi: 10.1007/s11427-021-2072-4

Differences in intestinal microbiome are associated with the mortality of COVID-19 patients in intensive care units

Dong Wu 1,2,#, Kaichen Zhou 3,#, Meng Xiao 2,4,#, Zhihua Liu 3,✉, Shuyang Zhang 2,5,✉
PMCID: PMC8853374  PMID: 35167017

The content is available as a PDF (828.5 KB).

Electronic supplementary material

11427_2021_2072_MOESM1_ESM.pdf (50.3KB, pdf)

Supplementary Table 1. Clinical Characteristics of the Study Population

11427_2021_2072_MOESM2_ESM.pdf (290.4KB, pdf)

Supplementary material, approximately 287 KB.

Acknowledgements

This work was supported by the National Key Research and Development Program of China (2020YFC0861000 and 2018YFE0207300), Beijing Nova Program (Z201100006820127), and the CAMS Endowment Fund (2021-CAMS-JZ004). The study protocol was approved by the Research Ethical Committee of Peking Union Medical College Hospital (Approval No. SK1297).

Compliance and ethics The author(s) declare that they have no conflict of interest.

Footnotes

Contributed equally to this work

Contributor Information

Zhihua Liu, Email: zhihualiu@mail.tsinghua.edu.cn.

Shuyang Zhang, Email: shuyangzhang103@163.com.

References

  1. Carroll IM, Chang YH, Park J, Sartor RB, Ringel Y. Luminal and mucosal-associated intestinal microbiota in patients with diarrhea-predominant irritable bowel syndrome. Gut Pathog. 2010;2:1–9. doi: 10.1186/1757-4749-2-19. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Douglas GM, Maffei VJ, Zaneveld JR, Yurgel SN, Brown JR, Taylor CM, Huttenhower C, Langille MGI. PICRUSt2 for prediction of metagenome functions. Nat Biotechnol. 2020;38:685–688. doi: 10.1038/s41587-020-0548-6. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Gu S, Chen Y, Wu Z, Chen Y, Gao H, Lv L, Guo F, Zhang X, Luo R, Huang C, et al. Alterations of the gut microbiota in patients with coronavirus disease 2019 or H1N1 influenza. Clin Infect Dis. 2020;71:2669–2678. doi: 10.1093/cid/ciaa709. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Jeong HW, Kim SM, Kim HS, Kim YI, Kim JH, Cho JY, Kim SH, Kang H, Kim SG, Park SJ, et al. Viable SARS-CoV-2 in various specimens from COVID-19 patients. Clin Microbiol Infect. 2020;26:1520–1524. doi: 10.1016/j.cmi.2020.07.020. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Parasa S, Desai M, Thoguluva Chandrasekar V, Patel HK, Kennedy KF, Roesch T, Spadaccini M, Colombo M, Gabbiadini R, Artifon ELA, et al. Prevalence of gastrointestinal symptoms and fecal viral shedding in patients with coronavirus disease 2019. JAMA Netw Open. 2020;3:e2011335. doi: 10.1001/jamanetworkopen.2020.11335. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Zoetendal EG, von Wright A, Vilpponen-Salmela T, Ben-Amor K, Akkermans ADL, de Vos WM. Mucosa-associated bacteria in the human gastrointestinal tract are uniformly distributed along the colon and differ from the community recovered from feces. Appl Environ Microbiol. 2002;68:3401–3407. doi: 10.1128/AEM.68.7.3401-3407.2002. [DOI] [PMC free article] [PubMed] [Google Scholar]

Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

11427_2021_2072_MOESM1_ESM.pdf (50.3KB, pdf)

Supplementary Table 1. Clinical Characteristics of the Study Population

11427_2021_2072_MOESM2_ESM.pdf (290.4KB, pdf)

Supplementary material, approximately 287 KB.

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