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. 2022 Feb 19;77:103878. doi: 10.1016/j.ebiom.2022.103878

Figure 1.

Fig 1

B cells in COVID-19 and VHL-deficient mice. a, Cohort details. Time post positive swab (group A) or symptom onset (groups B-E). b, Median absolute cell counts (left) or proportions relative to total B cells (right) (log2 fold change relative to healthy controls). (Wilcoxon test FDR adjusted p-value (q)): *<0.05, **<0.005, ***<0.0005. c, Serum IgG and IgM (g/L) at enrolment. Grey band: 5-95th centiles of healthy reference range (see methods). Significant P values listed. d, Somatic hypermutation frequency in IgA and IgG within 0-12 days post symptom onset, calculated over the CDR1/CDR2 regions using BCR sequencing of whole blood. (Wilcoxon test). c,d, Circles represent individual donors. e, Phenotype comparison: COVID-19 patients versus mice with Vhl-deficient B cells.