Extended Data Table 1.
Data collection and refinement statistics
| sEGFRR84K-epiregulin PDB: 7LEN |
sEGFRA265V-epiregulin PDB: 7LFS |
|
|---|---|---|
| Data collection a | ||
| Space group | P 21 21 21 | P2i |
| Cell dimensions | ||
| a, b, c (A) | 77.74, 86.60, 197.79 | 77.97, 201.33, 92.15 |
| α, β, γ (°) | 90.00, 90.00, 90.00 | 90.00, 99.04, 90.00 |
| Resolution (Å) | 50.0 – 2.9 (3.1 – 2.9)b | 50.0 – 3.5 (3.7 – 3.5) |
| R sym | 0.134 (1.35) | 0.075 (1.20) |
| I / σ/ | 10.9 (1.3) | 8.4 (1.1) |
| CC1/2 c | 0.489 | 0.473 |
| Completeness (%) | 99.8 (99.0) | 99.2 (97.0) |
| Redundancy | 6.7 (6.5) | 3.5 (3.6) |
| Refinement | ||
| Resolution (Å) | 43.48 – 2.90 | 48.06 – 3.50 |
| No. reflections | 30250 (2683) | 35030 (2789) |
| Rwork / Rfree | 0.237/0.295 | 0.266/0.315 |
| No. atoms | ||
| Protein | 8423 | 16443 |
| B-factors | ||
| Protein | 82.0 | 99.0 |
| R.m.s. deviations | ||
| Bond lengths (Å) | 0.007 | 0.002 |
| Bond angles (°) | 1.164 | 0.546 |
a
Each dataset was collected from a single crystal.
b
Values in parentheses are for highest-resolution shell.
c
CC1/2 reported for the highest-resolution shell.