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. 2021 Apr 8;71(3):627–642. doi: 10.1136/gutjnl-2020-323585

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Substitution networks emerging in NS5B-palm domain under sofosbuvir treatment. (A) ED43 full-length cultures were treated with sofosbuvir and analysed by NGS. Treatment was initiated with 1x-EC₅₀, then increased to 2x-EC₅₀ at day 9. (B) Efficacy of sofosbuvir against indicated ED43 full-length DAA escape viruses. Values are means of triplicates±SEM. (C) Fitness of ED43 recombinant viruses harbouring RAS NS5B-S282T. For details, see figure 2 legend. NGS, next-generation sequencing; SEM, standard error of the mean.