Table 4.
Adjusted hazard ratios for maternal body mass index, rate of early pregnancy weight gain, total pregnancy weight gain, and birth weight and colorectal cancer in adult offspring
| Person-years | n | aHR1 | 95% CI | p-value | |
|---|---|---|---|---|---|
| Maternal body mass index | 0.02 | ||||
| Underweight/healthy | 477,430 | 32 | 1.00 | ||
| Overweight | 121,235 | 18 | 2.12 | 1.18, 3.82 | |
| Obese | 43,117 | 7 | 2.51 | 1.05, 6.02 | |
| Rate of early weight gain2 | 625,752 | 50 | 1.17 | 0.71, 1.95 | 0.54 |
| Quartile 1 | -- | -- | 1.07 | 0.87, 1.31 | |
| Quartile 2 | -- | -- | 1.12 | 0.78, 1.61 | |
| Quartile 3 | -- | -- | 1.16 | 0.72, 1.86 | |
| Quartile 4 | -- | -- | 1.22 | 0.65, 2.31 | |
| Total weight gain2 | 689,740 | 60 | 1.03 | 0.99, 1.08 | 0.15 |
| Quartile 1 | -- | -- | 1.47 | 0.88, 2.47 | |
| Quartile 2 | -- | -- | 1.78 | 0.82, 3.88 | |
| Quartile 3 | -- | -- | 2.09 | 0.77, 5.65 | |
| Quartile 4 | -- | -- | 2.54 | 0.72, 8.88 | |
| Birth weight | 0.17 | ||||
| < 2,500 g | 42,973 | 3 | 0.44 | 0.06, 3.15 | |
| 2,500g – 3,999g | 631,307 | 56 | 1.00 | ||
| ≥ 4,000g | 63,768 | 9 | 1.95 | 0.86, 4.38 | |
Abbreviations: aHR, adjusted hazard ratio; CI, confidence interval
Adjusted hazard ratios derived from main effects models; maternal BMI adjusted for race/ethnicity; rate of early weight gain adjusted for race/ethnicity, maternal BMI, and gestational age; total weight gain adjusted for race/ethnicity, maternal BMI, rate of early weight gain, and gestational age; birth weight adjusted for race/ethnicity, maternal BMI, rate of early weight gain, and total weight gain
aHRs and their 95% CIs at the median of each quartile of the rate of early weight gain (0.40, 0.71, 0.93, and 1.25 pounds per week) and total weight gain (12, 18, 23, and 29 pounds)