Figure 1 |. Structure of the σ₂ receptor and binding site ligand recognition.

a, Structure of the σ₂ receptor bound to PB28. Amino- and carboxy-termini are indicated. Membrane boundaries were calculated using the PPM server³¹. b, Cross-section of the σ₂ receptor binding pocket (left) and view of the entrance to the binding pocket from the membrane (right). c, View of PB28 binding pose, showing charge–charge interaction with Asp29 (black dotted line) and contacts with other binding pocket residues. d, Analogous structure of the roluperidone binding pose. e, Structure of the σ₁ receptor bound to PD144418 (PDB ID: 5HK1). Amino acids that serve similar roles and positioned in a similar orientation to amino acids in the σ₂ receptor are indicated.