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. Author manuscript; available in PMC: 2022 Jun 8.
Published in final edited form as: Nature. 2021 Dec 8;600(7890):759–764. doi: 10.1038/s41586-021-04175-x

Extended Data Figure 5 |. Off-target profiling of Z4446724338, Z1665845742, and Z4857158944.

Extended Data Figure 5 |

a-c, TANGO screens against a panel of 320 GPCRs for the indicated σ2 ligand. a, Z4446724338, b, Z1665845742, c, Z4857158944. d, GloSensor μOR-mediated cAMP inhibition (Gi activation) by DAMGO, Z4446724338, Z1665845742, and Z4857158944. e-f, Follow-up does-response curves for pain-related receptors that showed activation in a-c. e, Z4446724338 and Z1665845742 against 5HT1A. f, Z4857158944 against κOR. Data shown are means ± SEM.