Table 1.

Radiosensitizing effects of curcumin on different cancer models.

Cancer Site	Subject	Curcumin Dosage	Effect	Ref.
Lung	Human A549 cells	10 μΜ	Ιncrease in IR-induced reduction of cell viability via inhibition of EGFR protein	[33]
	Human A549 cells	5–20 μΜ	Inhibition of migration, invasion through suppression of radiation-induced EMT	[35]
	Xenograft model of A549 cells	20 uM	Induction of apoptosis	[38]
Nasopharynx	Human nasopharyngeal carcinoma (NPC) cells	10 μΜ	Increase in radiosensitivity through depression of MDR1 expression	[39]
	Human NPC cell line CNE-2	20 μΜ	Increase in IR-induced cell death through modulation of circRNAs	[40]
Breast	Human MCF10A, MCF7 and MDA-MB-231 BC cells	2.5–10 μΜ	Deregulation of molecules involved in the induction of apoptosis, in the inflammatory process, in the cell cycle, and tyrosine metabolism	[42]
	Breast cancer stem cells	30 μΜ	Reduction of RT resistance through inhibition of HIF-1a, HSP90	[43]
Prostate	Human PC-3, DU145, and LNCaP cells	30 μΜ	Increase in IR-induced apoptosis/reduction in the expression of DNMT1 and DNMT3B	[46]
	DU145 and PC-3 cells	0.1–0.4 µg/mL	Tumor growth suppression, decreased invasion, and migration	[47]
Cervix	Human HeLa cells	40 μΜ	Increased cell cytotoxicity of the combination	[44]
	Cervical carcinoma stage IIB–IIIB patients	4 g/day	Decreased levels of surviving	[45]
CNS	LN229 and U251 glioma cells	20 μΜ	Reduction in cell migration and invasion/inhibition of the Hedgehog signaling pathway	[48]
	U87 and T98 human glioma cells	10–20 μΜ	Increased cytotoxicity and G2/M arrest	[49]
	Orthotopic F98/FGT glioma-bearing rat model.	5-20 μΜ	Suppression of the growth of in situ brain tumors	[50]
Esophagus	Human ESCC-07, ESCC-12, ESCC-19, ESCC-27 and ESCC-31 cell lines	10 μΜ	Increase in IR-induced apoptosis/Inhibition of Nf-Kb signaling	[51]
	ESCC-07 xenograft mice	10 μΜ	Decrease in tumor volume and weight	[51]
Colon	Human colon cancer HT-29 cells	2.5 μΜ	Inhibition of cell proliferation/modulation of expression of DNA repair-related genes	[52]
	HT-29 bearing mice	2.5 μΜ	Intratumoral apoptosis and suppression of neoplastic growth	[52]
Pancreas	Human Panc-1 and MiaPaCa-2 cells	6 or 12 μΜ	Increased cytotoxicity and G2/M arrest	[53]
Kidney	Renal ACHN cancer cells	5–80 μΜ	Increased cell death, suppression of the NF-κB signaling pathway	[54]
	ACHN tumor-bearing nude mice	5–80 μΜ	Decrease in tumor volume increased apoptosis	[54]
Urinary Bladder	Urinary bladder cancer T24 cells	10 μΜ	Inhibition of p53 nuclear transcription factor	[55]