Table 1.
Cancer Site | Subject | Curcumin Dosage | Effect | Ref. |
---|---|---|---|---|
Lung | Human A549 cells | 10 μΜ | Ιncrease in IR-induced reduction of cell viability via inhibition of EGFR protein |
[33] |
Human A549 cells | 5–20 μΜ | Inhibition of migration, invasion through suppression of radiation-induced EMT | [35] | |
Xenograft model of A549 cells | 20 uM | Induction of apoptosis | [38] | |
Nasopharynx | Human nasopharyngeal carcinoma (NPC) cells | 10 μΜ | Increase in radiosensitivity through depression of MDR1 expression | [39] |
Human NPC cell line CNE-2 | 20 μΜ | Increase in IR-induced cell death through modulation of circRNAs | [40] | |
Breast | Human MCF10A, MCF7 and MDA-MB-231 BC cells | 2.5–10 μΜ | Deregulation of molecules involved in the induction of apoptosis, in the inflammatory process, in the cell cycle, and tyrosine metabolism | [42] |
Breast cancer stem cells | 30 μΜ | Reduction of RT resistance through inhibition of HIF-1a, HSP90 | [43] | |
Prostate | Human PC-3, DU145, and LNCaP cells | 30 μΜ | Increase in IR-induced apoptosis/reduction in the expression of DNMT1 and DNMT3B | [46] |
DU145 and PC-3 cells | 0.1–0.4 µg/mL | Tumor growth suppression, decreased invasion, and migration | [47] | |
Cervix | Human HeLa cells | 40 μΜ | Increased cell cytotoxicity of the combination | [44] |
Cervical carcinoma stage IIB–IIIB patients | 4 g/day | Decreased levels of surviving | [45] | |
CNS | LN229 and U251 glioma cells | 20 μΜ | Reduction in cell migration and invasion/inhibition of the Hedgehog signaling pathway | [48] |
U87 and T98 human glioma cells | 10–20 μΜ | Increased cytotoxicity and G2/M arrest | [49] | |
Orthotopic F98/FGT glioma-bearing rat model. | 5-20 μΜ | Suppression of the growth of in situ brain tumors | [50] | |
Esophagus | Human ESCC-07, ESCC-12, ESCC-19, ESCC-27 and ESCC-31 cell lines | 10 μΜ | Increase in IR-induced apoptosis/Inhibition of Nf-Kb signaling | [51] |
ESCC-07 xenograft mice | 10 μΜ | Decrease in tumor volume and weight | [51] | |
Colon | Human colon cancer HT-29 cells | 2.5 μΜ | Inhibition of cell proliferation/modulation of expression of DNA repair-related genes | [52] |
HT-29 bearing mice | 2.5 μΜ | Intratumoral apoptosis and suppression of neoplastic growth | [52] | |
Pancreas | Human Panc-1 and MiaPaCa-2 cells | 6 or 12 μΜ | Increased cytotoxicity and G2/M arrest | [53] |
Kidney | Renal ACHN cancer cells | 5–80 μΜ | Increased cell death, suppression of the NF-κB signaling pathway | [54] |
ACHN tumor-bearing nude mice | 5–80 μΜ | Decrease in tumor volume increased apoptosis | [54] | |
Urinary Bladder | Urinary bladder cancer T24 cells | 10 μΜ | Inhibition of p53 nuclear transcription factor | [55] |