Table 5.
Relationship between AhR transcript levels and classical clinical parameters in all GCs and subtypes. Median (range) of gene mRNA expression levels; p value (Mann Whitney). ND, not determined.
| All Tumors n = 29 | Intestinal Sub-Type n = 16 | Diffuse Sub- Type n = 13 |
|||
|---|---|---|---|---|---|
| AhR | AhR | AhR | |||
| Gender. | p = 0.51 | Gender. | p = 0.19 | Gender. | p = 0.81 |
| Male (n = 13) | 1.54 (0.55–3.33) | Male (n = 7) | 1.71 (0.89–2.84) | Male (n = 6) | 1.51 (0.87–3.08) |
| Female (n = 16) | 1.35 (0.65–3.53) | Female (n = 9) | 1.16 (0.89–1.83) | Female (n = 7) | 1.58 (1.22–2.01) |
| Age | p = 0.82 | Age | ND | Age | p = 0.72 |
| <60 years (n = 9) | 1.94 (0.55–3.35) | <60 years (n = 1) | 1.38 (0.89–1.83) | <60 years (n = 8) | 1.51 (0.87–2.01) |
| >60 years (n = 20) | 1.80 (0.65–3.53) | >60 years (n = 15) | 1.16 (0.90–2.84) | >60 years (n = 5) | 1.58 (1.22–3.08) |
| Tumor invasion | p = 0.21 | Tumor invasion | ND | Tumor invasion | ND |
| T1–T2 (n = 6) | 1.45 (0.65–2.86) | T1–T2 (n = 4) | 0.93 (0.9–0.96) | T1–T2 (n = 2) | 1.42 (1.27–1.58) |
| T3–T4 (n = 23) | 1.94 (0.55–3.53) | T3–T4 (n = 12) | 1.55 (0.89–2.84) | T3–T4 (n = 11) | 1.53 (0.9–3.1) |
| Vascular invasion | p = 0.14 | Vascular invasion | p = 0.79 | Vascular invasion | p>0.9999 |
| negative (n = 9) | 1.25 (0.82–2.96) | negative (n = 6) | 1.21 (1.18–1.72) | negative (n = 3) | 1.53 (1.32–1.63) |
| positive (n = 20) | 2.05 (0.55–3.53) | positive (n = 10) | 1.35 (0.89–2.84) | positive (n = 10) | 1.53 (0.87–3.08) |
| Lymphatic invasion | p = 0.11 | Lymphatic invasion | ND | Lymphatic invasion | ND |
| negative (n = 11) | 1.25 (0.65–3.18) | negative (n = 10) | 1.18 | negative (n = 1) | 1.53 |
| positive (n = 17) | 2.11 (0.55–3.53) | positive (n = 5) | 1.38 (0.89–2.84) | positive (n = 12) | 1.53 (0.87–3.08) |
| Metastasis | p = 0.92 | Metastasis | ND | Metastasis | p = 0.93 |
| negative (n = 24) | 1.96 (0.55–3.53) | negative (n = 15) | 1.71 (0.89–2.84) | negative (n = 9) | 1.49 (0.87–3.08) |
| positive (n = 5) | 2.1 (0.82–2.55) | positive (n = 1) | 1.19 (1.16–1.55) | positive (n = 4) | 1.58 (1.22–2.01) |
| TNM | p = 0.30 | TNM | p = 0.80 | TNM | p = 0.21 |
| I–II (n = 16) | 1.77 (0.54–3.35) | I–II (n = 11) | 1.71 (0.89–1.83) | I–II (n = 5) | 1.32 (0.87–1.9) |
| III–IV (n = 13) | 2.11 (0.82–3.53) | III–IV (n = 5) | 1.19 (0.9–2.84) | III–IV (n = 8) | 1.6 (1.22–3.08) |
| EPN | p = 0.47 | EPN | ND | EPN | ND |
| negative (n = 6) | 1.58 (0.90–2.86) | negative (n = 4) | 0.93 (0.9–0.96) | negative (n = 2) | 1.42 (1.27–1.58) |
| positive (n = 23) | 1.94 (0.55–3.53) | positive (n = 12) | 1.55 (0.89–2.84) | positive (n = 11) | 1.53 (0.9–3.1) |
| Smoking | p = 0.85 | Smoking | p = 0.74 | Smoking | p = 0.63 |
| negative (n = 12) | 1.77 (0.55–3.35) | negative (n = 8) | 1.19 (0.89–1.71) | negative (n = 4) | 1.51 (0.87–1.63) |
| positive (n = 10) | 1.85 (0.82–3.53) | positive (n = 7) | 0.96 (0.9–1.55) | positive (n = 3) | 1.58 (1.27–2.01) |