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. 2022 Feb 21;11(4):745. doi: 10.3390/cells11040745

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Overview of ischemia-reperfusion injury (IRI) at the cellular level in the lung graft during and after LTx. (A) Cessation of flow or ischemia in the alveolar capillaries sets off IRI. (B) Phase of donor-derived inflammation initiates the innate immune response after reperfusion. (C) Phase of recipient-derived inflammation that further precipitates injury in the lung. (Created with BioRender.com). DAMP = damage associated molecular pattern; NK = natural killer; ROS = reactive oxygen species.