Skip to main content
Springer logoLink to Springer
editorial
. 2021 Oct 2;41(3):939–941. doi: 10.1007/s10067-021-05897-z

Gouty tophus erodes nasal bone

Eva Rottmann 1,, David Bulbin 1, Anthony Zaklama 2
PMCID: PMC8873052  PMID: 34599715

Presentation

A 45-year-old Asian man with a 20-year history of gout is seen in clinic after lost to follow up for 10 years. He was previously treated with allopurinol but had been off therapy for many years. He describes several weeks of nasal bridge swelling with new episodes of snoring and apnea. On exam, he has a tender, erythematous mass over dorsum of nose with bulky tophi of multiple joints on hands, elbows, knees, and feet. Point-of-care ultrasound of his nasal bridge shows an area of inhomogeneous, hyperechoic aggregation with a hypoechoic rim consistent with gouty tophus [1]. Sinus CT without contrast shows a soft tissue partially calcified mass with bilateral nasal bone erosions. His uric acid was 12.6 mg/dl. This case is a rare presentation of gouty tophi causing nasal bone erosions. The patient tested negative for hereditary enzyme deficiencies. He did test positive for HLA-B*5801 putting him at risk for allopurinol hypersensitivity syndrome. He was treated with febuxostat and eventually pegloticase infusions. With urate lowering therapy, his nasal mass size decreased, and apnea improved without need for surgical intervention (Fig. 1).

Fig. 1.

Fig. 1

A Tender mass over nose. B Ultrasound of nasal bridge longitudinal view. C Transverse view—an area of inhomogeneous, hyperechoic aggregation with irregular margins, associated shadowing, and a surrounding hypoechoic rim compatible with a “wet clumps of sugar” appearance (white arrow). D Sinus CT without contrast shows a soft tissue mass with focal calcifications (circle) immediately adjacent to nasal bone erosion (arrow)

Discussion

Gout is increasingly recognized as a systemic urate deposition disease and can involve extra-articular deposition into soft tissue, tendons, and even cardiovascular tissue [2]. However, gouty tophus with nasal bone destruction is still extremely rare with only a few cases noted in literature [3]. Pathology can confirm monosodium urate crystals [4]. Ultrasound findings of gout such as a double-contour sign (a hyperechoic line of MSU crystals overlying cartilage) or “wet clumps of sugar” are well described in literature and may spare need for invasive tissue confirmation in the appropriate clinical setting [5]. Apneic symptoms can improve with medical treatment alone as nasal tophi decreases; however, some cases of refractory nasal obstruction and septal deviation have required surgical excision [6].

Funding

Research is funded by Graduate Medical Education at Geisinger Medical Center.

Declarations

Disclosures

None.

Informed consent

Patient has consented to the publishing of data, photographs, and submission of the case report to the journal.

Footnotes

Publisher's note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Contributor Information

Eva Rottmann, Email: Evaoconnell1314@gmail.com.

David Bulbin, Email: dhbulbin@geisinger.edu.

Anthony Zaklama, Email: azaklama@geisinger.edu.

References

  • 1.Terslev L, Gutierrez M, Schmidt WA, Keen HI, Filippucci E, Kane D, Thiele R, Kaeley G, Balint P, Mandl P, Delle Sedie A, Hammer HB, Christensen R, Möller I, Pineda C, Kissin E, Bruyn GA, Iagnocco A, Naredo E, D’Agostino MA, OMERACT Ultrasound Working Group Ultrasound as an outcome measure in gout A validation process by the OMERACT Ultrasound Working Group. J Rheumatol. 2015;42(11):2177–81. doi: 10.3899/jrheum.141294. [DOI] [PubMed] [Google Scholar]
  • 2.Klauser AS, Halpern EJ, Strobl S, et al. Dual-energy computed tomography detection of cardiovascular monosodium urate deposits in patients with gout. JAMA Cardiol. 2019;4(10):1019–1028. doi: 10.1001/jamacardio.2019.3201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 3.Chen SL, Chen JR, Yang SW. Painless gouty tophus in the nasal bridge: a case report and literature review. Medicine (Baltimore) 2019;98(11):e14850. doi: 10.1097/MD.0000000000014850. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 4.Wu JC, Chou PY, Chen CH. Nasal gouty tophus: report a rare case presenting as a nasal hump with nasal obstruction. Biomed J. 2016;39(4):295–297. doi: 10.1016/j.bj.2016.05.002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  • 5.Thiele RG. Role of ultrasound and other advanced imaging in the diagnosis and management of gout. Curr Rheumatol Rep. 2011;13(2):146–153. doi: 10.1007/s11926-010-0156-4. [DOI] [PubMed] [Google Scholar]
  • 6.Kwak PE, Gorman BK, Olson KL. Nasal gout presenting as nasal obstruction. JAMA Otolaryngol Head Neck Surg. 2013;139(4):411–413. doi: 10.1001/jamaoto.2013.220. [DOI] [PubMed] [Google Scholar]

Articles from Clinical Rheumatology are provided here courtesy of Springer

RESOURCES