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. 2022 Feb 19;12(2):192. doi: 10.3390/metabo12020192

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Heatmap illustrating fold changes and differences in plasma polyunsaturated fatty acids (PUFAs) and lipid mediators between non-alcoholic steatohepatitis (NASH) compared to NASH-free (0-NASH) in primary cohort. Fold changes are indicated by color and intensity, with red indicating an increase, and blue indicating a decrease. Lipids different in NASH vs. 0-NASH (t-test raw p < 0.05) are noted by (*). Ethnicity-related differences, or interaction (ethnicity × NASH) (ANCOVA raw p < 0.05) are marked with bold red color. C18 PUFAs and related lipids are marked with “green”; long chain-PUFAs and related lipids are marked with “yellow”; saturated fatty acids (SFA) and monounsaturated fatty acid (MUFA) related lipids are marked with “grey”. Means and p-values are detailed in Table S3. Fatty acids are described by number of carbons and double bounds of the fatty acyl moiety (i.e., C18:2n6). NASH (n = 6 Hispanic (HIS) and 3 Caucasian (CAU); 0-NASH (n = 4 HIS and 5 CAU). ADH, alcohol dehydrogenase; AEA, arachidonoyl ethanolamine; AG, arachidonoyl glycerol; DEA, docosatetraenyl ethanolamide; DGLEA, dihomo-gamma-linolenoyl ethanolamide; DH, dehydrogenase; DHEA, docosahexaenoyl ethanolamide; DiHDoPA, dihydroxydocosapentaenoic acid; DiHETE, dihydroxyeicosatetraenoic acid; DiHETrE, dihydroxyeicosatrienoic acid; DiHO, dihydroxyoctadecanoic acid; DiHODE, dihydroxyoctadecadienoic acid; DiHOME, dihydroxyoctadecenoic acid; Elov, fatty acid elongase; Ep-KODE, epoxyoxooctadecenoic acid; EpETE, epoxyeicosatetraenoic acid; EpODE, epoxyoctadecadienoic acid; EpOME, epoxyoctadecenoic acid; F2-IsoP, F2 isoprostanes; FAAH, fatty acid amide hydrolase; Fads, fattyaciddesaturase; HDoHE, hydroxydocosahexaenoic acid; HEPE, hydroxyeicosapentaenoic acid; HETE, hydroxyeicosatetraenoic acid; HODE, hydroxyoctadecadienoic acid; HOTE, hydroxyoctadecatrienoic acid; HpODE, hydroperoxyoctadecadienoic acid; KETE, keto-eicosatetraenoic; KODE, keto-octadecadienoic acid; LEA, Linoleyl ethanolamine; LG, linoleoylglycerol; LOX, lipoxygenase; NA-Gly, arachidonylglycine; NAPES, N-acylphosphatidyl ethanolamine-specific; NO-Gly; OEA, oleoyl ethanolamine; OG, oleoylglycerol; PEA, palmitoyl ethanolamine; PGE, prostaglandin E; PGF, prostaglandin F; POEA, palmitoleoyl ethanolamide; SEA, stearoyl ethanolamide; sEH, soluble epoxide hydrolase; TriHOME, trihydroxyoctadecaenoic acid; TXB, thromboxane.