Table 5.

Histological characteristics of the normal skin epithelium and skin epithelium after induction of verrucous cell carcinoma.

Normal Skin	Skin with Induced Verrucous Cell Carcinoma
Preserved architecture	Architecture altered
Epidermis normal keratinized stratified squamous epithelium. Polarization of the layers of the preserved epidermis. No thickening	Altered epidermis, loss of polarity of keratinocytes, cellular atypia, loss of nucleus-cytoplasm ratio, evident central nucleolus
Intact basement membrane	Infiltrated basement membrane
No ulceration	present ulceration
Present and typical mitosis (bipolar)	Tripolar (Y) and tetrapolar (X) increased and atypical mitosis