Figure 2.

HTS for inhibitors of SARS-CoV-2 entry from a botanical drug library. (A) HTS assay flowchart. (B) HTS of a library of 1037 natural extracts for primary candidates inhibiting SARS-CoV-2 S pv (ct19) infection. Each dot represents the percent inhibition achieved by each compound at a concentration of 50 μM. (C) Inhibition of 58 candidates against SARS-CoV-2 S pv entry > 80%. The second screen of the 58 selected compounds. VSV pv was used as a control to exclude compounds targeting the backbone. The hits depicted in red box showed mild inhibition of VSV pv infection and were designated hits.