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. Author manuscript; available in PMC: 2022 Feb 25.
Published in final edited form as: Neuron. 2019 Feb 4;101(6):1134–1149.e3. doi: 10.1016/j.neuron.2019.01.011

Figure 6. CaV CDI Model.

Figure 6.

Closed channels (left) are activated by depolarization that includes voltage sensor domain (VSD) activation and pore opening. Flow of Ca2+ through the channel leads to Ca2+ (white circles) binding to CaM (green) that initiates CDI. CDI results in a selectivity filter (SF) conformational change that obstructs ion flow. Pore domain, PD (violet), voltage sensor domain, VSD (cyan), and SF (black) are labeled. Gray bars indicate membrane. Other intracellular elements that affect CDI such as the N-terminal cytoplasmic domain and CaVβ/I-II loop complex are not shown.