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. 2021 Nov 8;47(4):914–923. doi: 10.1038/s41386-021-01221-0

Fig. 2. Effects of 3-APBT, 5-APBT, and 6-APBT on locomotor activity and HTR in mice.

Fig. 2

A–D APBT-treated mice received s.c. injections of 0.01–30 mg/kg s.c. 3-APBT, 5-APBT, 6-APBT, or vehicle (saline 0.9%). Locomotor activity was assessed over 60 min following habituation and drug injections. MDMA (30 mg/kg), 5-APB (10 mg/kg), and 6-APB (10 mg/kg) were administered s.c. as positive controls that are known to produce locomotor stimulation in mice. Data are mean ± SEM for n = 5 mice per group and were compared via one-way ANOVA with Dunnett’s post hoc test comparing all groups to 0 mg/kg vehicle controls (****P < 0.0001, **P < 0.01, *P < 0.05). E–G Effect of 3-APBT, 5-APBT, and 6-APBT on the HTR in mice. Data are presented as group means ± SEM. ****P < 0.0001, ***P < 0.001, **P < 0.01, *P < 0.05 indicate significant difference from the vehicle control group (Dunnett’s test).