In the original article, there was an error. In the Abstract there was a mistake in the statement of the results of the pooled prevalence of congenital myopathy in the all-age population. Instead of “The pooled prevalence of congenital myopathy in the all-age population was 1.50 (95% CI, 0.93–2.06) per 100,000, while the prevalence in the child population was 2.73 (95% CI, 1.34–4.12) per 100,000”, it should be “The pooled prevalence of congenital myopathy in the all-age population was 1.62 (95% CI, 1.13–2.11) per 100,000, while the prevalence in the child population was 2.76 (95% CI, 1.34–4.18) per 100,000.”
A correction has been made to Abstract, Results, Paragraph 1:
Results: A total of 11 studies were included in the systematic review and meta-analysis. Of the 11 studies included, 10 (90.9%) were considered medium-quality, one (9.1%) was considered low-quality, and no study was assessed as having a high overall quality. The pooled prevalence of congenital myopathy in the all-age population was 1.62 (95% CI, 1.13–2.11) per 100,000, while the prevalence in the child population was 2.76 (95% CI, 1.34–4.18) per 100,000. In the pediatric population, the prevalence among males was 2.92 (95% CI, −1.70 to 7.55) per 100,000, while the prevalence among females was 2.47 (95% CI, −1.67 to 6.61) per 100,000. The prevalence estimates of the all-age population per 100,000 were 0.20 (95% CI 0.10–0.35) for nemaline myopathy, 0.37 (95% CI 0.21–0.53) for core myopathy, 0.08 (95% CI −0.01 to 0.18) for centronuclear myopathy, 0.23 (95% CI 0.04–0.42) for congenital fiber-type disproportion myopathy, and 0.34 (95% CI, 0.24–0.44) for unspecified congenital myopathies. In addition, the prevalence estimates of the pediatric population per 100,000 were 0.22 (95% CI 0.03–0.40) for nemaline myopathy, 0.46 (95% CI 0.03–0.90) for core myopathy, 0.44 (95% CI 0.03–0.84) for centronuclear myopathy, 0.25 (95% CI −0.05 to 0.54) for congenital fiber-type disproportion myopathy, and 2.63 (95% CI 1.64–3.62) for unspecified congenital myopathies.
In the original article, there was a mistake in Table 1 as published. The number of cases in the reference Norwood et al. should be 41, not 18. The corrected Table 1 appears below.
Table 1.
Characteristics of the included studies on congenital myopathy prevalence.
| References | Country/region | Age (years) | Data source | Diagnostic criteria | Prevalence date | Population size | Number of cases | Prevalence per 100,000 (95% CI) | Overall scored |
|---|---|---|---|---|---|---|---|---|---|
| Amburgey et al. (21) | United States (Michigan) | <18 | Hospital/clinic chart review, administrative database | Clinical history with at least 1 additional supporting study (biopsy, genetic testing, or first-degree relative) | 2010 | 1,211,100 | 46 | 3.80 (2.93, 4.66) | Medium |
| Chung et al. (22) | Southern China (Hong Kong) | <19 | Hospital/clinic chart review, administrative database | European Neuromuscular Center (23), World Federation of Neurology Research Committee (24)a | 2001.06.30 | 1,335,469 | 45 | 3.22 (2.43, 4.01) | Medium |
| Darin and Tulinius (25) | Western Sweden | <16 | Mailed survey, hospital/clinic chart review, administrative databases | Muscle and Nerve (26)b | 1995.01.01 | 359,676 | 18 | 5.01 (3.37, 6.64) | Medium |
| Hughes et al. (27) | Northern Ireland | All | Hospital/clinic chart review, administrative database, relatives. | European Neuromuscular Center (23), World Federation of Neurology Research Committee (24)a | 1994.06.30 | 1,573,282 | 57 | 3.62 (2.87, 4.37) | Medium |
| Lefter et al. (28) | Ireland | >18 | Hospital/clinic chart review, administrative database | Table e-1 at Neurology.org (28) | 2013.12.31 | 3,439,565 | 33 | 0.96 (0.65, 1.27) | Medium |
| Norwood et al. (29) | Northern England | All | Hospital/clinic chart review, administrative database | European Neuromuscular Center (23), Monogenic neuromuscular disorders (30)c | 2007.08.01 | 2,990,000 | 41 | 0.60 (0.33, 0.87) | Medium |
| Pagola-Lorz et al. (31) | Northern Spain (Navarre) | All | Hospital/clinic chart review, administrative database | Monogenic neuromuscular disorders (32), undiagnosed genetic muscle disease (33)c | 2016 | 640,647 | 8 | 1.25 (0.44, 2.06) | Medium |
| Santos et al. (34) | Portugal | <15 | NM | Details are not available | 2001 | 1,656,602 | 27 | 1.63 (1.07, 2.19) | Low |
| Tangsrud and Halvorsen (35) | Southern Norway | <18 | Mailed survey, hospital/clinic chart review | System proposed by Dubowitz (36)b | 1983.01.01 | 573,762 | 3 | 0.52 (−0.05, 1.10) | Medium |
| Theadom et al. (37) | New Zealand | All | Hospital/clinic chart review, administrative database | Details are not available | 2014.04.01 | 4,242,048 | 60 | 1.41 (1.08, 1.75) | Medium |
| Witting et al. (38) | Denmark | >5 | Mailed survey, hospital/clinic chart review, administrative database | Highly dependent on histological findings | NM | 5,400,000 | 82 | 1.52 (1.22, 1.82) | Medium |
CI, confidence interval; NM, not mentioned.
Diagnosis based on characteristic histochemical abnormalities.
Highly dependent on histological findings.
Genetic confirmation or clinical phenotype + characteristic histological findings.
Quality of study reporting assessment; details are shown in Supplementary Material 2.
The authors apologize for these errors and state that they do not change the scientific conclusions of the article in any way. The original article has been updated.
Publisher's Note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
References
- 21.Amburgey K, Mcnamara N, Bennett LR, Mccormick ME, Acsadi G, Dowling JJ. Prevalence of congenital myopathies in a representative pediatric united states population. Ann Neurol. (2011) 70:662–5. 10.1002/ana.22510 [DOI] [PubMed] [Google Scholar]
- 22.Chung B, Wong V, Ip P. Prevalence of neuromuscular diseases in Chinese children: a study in southern China. J Child Neurol. (2003) 18:217–9. 10.1177/08830738030180030201 [DOI] [PubMed] [Google Scholar]
- 23.Dubowitz V. Diagnostic criteria for neuromuscular disorders: Edited by Alan E. H. Emery. Published 1994, European Neuromuscular Centre, Baarn, The Netherlands. ISBN 90 261 0719 6, 72 pp. Neuromuscular Disord. (1994) 4:292–3. 10.1016/0960-8966(94)90038-8 [DOI] [Google Scholar]
- 24.World Federation of Neurology Research Committee Research Group on Neuromuscular Diseases. J Neurol Sci. (1988) 86, 333–360. [PubMed] [Google Scholar]
- 25.Darin N, Tulinius M. Neuromuscular disorders in childhood: a descriptive epidemiological study from western Sweden. Neuromuscul Disord. (2000) 10:1–9. 10.1016/S0960-8966(99)00055-3 [DOI] [PubMed] [Google Scholar]
- 26.Brooke MH, Carroll JE, Ringel SP. Congenital hypotonia revisited. Muscle Nerve. (1979) 2:84–100. 10.1002/mus.880020203 [DOI] [PubMed] [Google Scholar]
- 27.Hughes MI, Hicks EM, Nevin NC, Patterson VH. The prevalence of inherited neuromuscular disease in Northern Ireland. Neuromuscul Disord. (1996) 6:69–73. 10.1016/0960-8966(94)00017-4 [DOI] [PubMed] [Google Scholar]
- 28.Lefter S, Hardiman O, Ryan AM. A population-based epidemiologic study of adult neuromuscular disease in the Republic of Ireland. Neurology. (2017) 88:304–13. 10.1212/WNL.0000000000003504 [DOI] [PubMed] [Google Scholar]
- 29.Norwood FL, Harling C, Chinnery PF, Eagle M, Bushby K, Straub V. Prevalence of genetic muscle disease in Northern England: in-depth analysis of a muscle clinic population. Brain. (2009) 132:3175–86. 10.1093/brain/awp236 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 30.Kaplan JC. Gene table of monogenic neuromuscular disorders (nuclear genome only) Vol 19. No 1 January 2009. Neuromuscul Disord. (2009) 19:77–98. 10.1016/j.nmd.2008.11.001 [DOI] [PubMed] [Google Scholar]
- 31.Pagola-Lorz I, Vicente E, Ibanez B, Torne L, Elizalde-Beiras I, Garcia-Solaesa V, et al. Epidemiological study and genetic characterization of inherited muscle diseases in a northern Spanish region. Orphanet J Rare Dis. (2019) 14:276. 10.1186/s13023-019-1227-x [DOI] [PMC free article] [PubMed] [Google Scholar]
- 32.Bonne G, Rivier F, Hamroun D. The 2018 version of the gene table of monogenic neuromuscular disorders (nuclear genome). Neuromuscul Disord. (2017) 27:1152–83. 10.1016/j.nmd.2017.10.005 [DOI] [PubMed] [Google Scholar]
- 33.Harris E, Laval S, Hudson J, Barresi R, De Waele L, Straub V, et al. Undiagnosed genetic muscle disease in the north of England: an in depth phenotype analysis. PLoS Curr. (2013) 5:ecurrents.md.37f840ca67f5e722945ecf755f40487e. 10.1371/currents.md.37f840ca67f5e722945ecf755f40487e [DOI] [PMC free article] [PubMed] [Google Scholar]
- 34.Santos MA, Fineza I, Moreno T, Cabral P, Ferreira JC, Silva RL, et al. G.P.7 07 Epidemiology of neuromuscular disorders in Portugal at pediatric age. Neuromuscular Disord. (2006) 16:703. 10.1016/j.nmd.2006.05.192 [DOI] [Google Scholar]
- 35.Tangsrud SE, Halvorsen S. Child neuromuscular disease in southern Norway. Prevalence, age and distribution of diagnosis with special reference to “non-Duchenne muscular dystrophy”. Clin Genet. (1988) 34:145–52. 10.1111/j.1399-0004.1988.tb02854.x [DOI] [PubMed] [Google Scholar]
- 36.Dubowitz V. Muscle disorders in childhood. Major Probl Clin Pediatr. (1978) 16:iii–xiii, 1–282. [PubMed] [Google Scholar]
- 37.Theadom A, Rodrigues M, Poke G, O'grady G, Love D, Hammond-Tooke G, et al. A Nationwide, population-based prevalence study of genetic muscle disorders. Neuroepidemiology. (2019) 52:128–35. 10.1159/000494115 [DOI] [PMC free article] [PubMed] [Google Scholar]
- 38.Witting N, Werlauff U, Duno M, Vissing J. Phenotypes, genotypes, and prevalence of congenital myopathies older than 5 years in Denmark. Neurol Genet. (2017) 3:e140. 10.1212/NXG.0000000000000140 [DOI] [PMC free article] [PubMed] [Google Scholar]