Figure 1.

Change in blood glucose measured during identical aerobic exercise sessions

(A) The change in glucose measured during eight identical exercise sessions across a 4-arm clinical study. The boxplot represents the median and IQR of the change in glucose measured during exercise, cross symbols represent outlier values and each whisker extends to the most extreme data point that is not an outlier (n = 158 observations of SMBG data from 20 participants, whereby each participant is represented by eight SMBG observations, and participant 18 is represented by six SMBG observations).

(B–E) The change in glucose measured during aerobic exercise within a given insulin therapy. The black x symbol represents the change in glucose measured during an exercise session, and there are two x symbols per participant per study arm. The line drawn between two black x symbols represents the difference in glucose outcomes measured between the two identically-designed exercise sessions (n = 158 observations of SMBG data from 20 participants across four study arms, whereby participants are represented by two observations per study arm, and data is not available for participant 18 in the standard of care study arm). The open black circle represents the change glucose measured from the start of exercise, to the minimum glucose measured 4 h after exercise, and these outcomes are connected by a dotted black line (n = 160 observations of CGM data from 20 participants across four study arms, whereby participants are each represented by two observations per study arm).