REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit monoclonal anti-p21 Waf1/Cip1	Cell Signaling Technology	Cat# 2947; RRID: AB_823586
Rabbit monoclonal anti-phospho-p38 MAPK (Thr180/Tyr182)	Cell Signaling Technology	Cat#4511; RRID: AB_2139682
Polyclonal anti-rabbit IgG, HRP-linked secondary antibody	Cell Signaling Technology	Cat#7074; RRID: AB_2099233
Polyclonal anti-mouse IgG, HRP-linked secondary antibody	Cell Signaling Technology	Cat#7076; RRID: AB_330924
Mouse monoclonal anti-p53 (DO-7)	Agilent	Cat#M7001; RRID: AB_2206626
Mouse monoclonal anti-Tyrosinase (T311)	Santa Cruz Biotechnology	Cat#sc-20035; RRID: AB_628420
Rabbit polyclonal anti-GAPDH	Sigma-Aldrich	Cat#G9545; RRID: AB_796208
Mouse monoclonal anti-alphaSMA	Sigma-Aldrich	Cat#A5228; RRID: AB_262054
Chemicals, peptides, and recombinant proteins
Quick Start™ Bradford 1x Dye Reagent	Bio-Rad Laboratories, Inc.	Cat#5000205
Prostaglandin D2 (IUPAC Name: (Z)-7-[(1R,2R,5S)-5-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid) (purity ≥98%)	Cayman Chemical	Cat#12010
Prostaglandin D2-d4 (IUPAC Name: (Z)-3,3,4,4-tetradeuterio-7-[(1R,2R,5S)-5-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-3-oxocyclopentyl]hept-5-enoic acid) (purity ≥99%)	Cayman Chemical	Cat#312010
Prostaglandin E2 (IUPAC Name: (Z)-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid) (purity ≥98%)	Cayman Chemical	Cat#14010
Prostaglandin E2-d4 (IUPAC Name: (Z)-3,3,4,4-tetradeuterio-7-[(1R,2R,3R)-3-hydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopentyl]hept-5-enoic acid) (purity ≥99%)	Cayman Chemical	Cat#314010
Prostaglandin F2α (IUPAC Name: (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(E,3S)-3-hydroxyoct-1-enyl]cyclopentyl]hept-5-enoic acid) purity ≥98%)	Cayman Chemical	Cat#16010
8-iso Prostaglandin F2α-d4 (IUPAC Name: 9α,11α,15S-trihydroxy-(8β)-prosta-5Z,13E-dien-1-oic-3,3,4,4-d4 acid) (purity ≥99%)	Cayman Chemical	Cat#316350
Leukotriene B4 (IUPAC Name: (5S,6Z,8E,10E,12R,14Z)-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid) (purity ≥97%)	Cayman Chemical	Cat#20110
Leukotriene B4-d4 (IUPAC Name: (5S,6Z,8E,10E,12R,14Z)-6,7,14,15-tetradeuterio-5,12-dihydroxyicosa-6,8,10,14-tetraenoic acid) (purity ≥99%)	Cayman Chemical	Cat#320110
Arachidonic acid (IUPAC Name: (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoic acid) >95.0% (GC)	Sigma-Aldrich	Cat#10931
Formic acid for LC-MS LiChropur™, 97.5-98.5% (T)	Sigma-Aldrich	Cat#00940
Palmitic acid (IUPAC Name: hexadecanoic acid) (purity ≥97%)	Cambridge Isotope Laboratories Inc.	Cat#DLM-2895-0.1
Cyclic Pifithrin-α hydrobromide (IUPAC name:2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole hydrobromide)	Sigma-Aldrich	Cat#P4236
β-Estradiol (IUPAC name: (17β)-estra-1,3,5(10)-triene-3,17-diol)	Sigma-Aldrich	Cat#E8875
Critical commercial assays
Human IL-6 ELISA Kit	Diaclone SAS	Cat#950.030.192; 2 x 96 (pre-coated)
Human IL-8 ELISA Kit	Diaclone SAS	Cat#950.050.192; 2 x 96 (pre-coated)
Human SCF ELISA Kit	Origene Technologies Inc.	Cat#EA102189
Human Endothelin ELISA Kit	Origene Technologies Inc.	Cat#EA100599
Human FGF1/FGF basic ELISA Kit	Origene Technologies Inc.	Cat#EA102179
Human AMSH(alpha-MSH) ELISA Kit	Wuhan Fine Biotech Co.	Cat#EH0792
Aurum™ Total RNA Mini kit	Bio-Rad Laboratories, Inc.	Cat#7326820
Experimental Models: Cell Lines
Immortalized human SZ95 sebocytes	Zouboulis CC Laboratory	N/A
Primary cultures of dermal fibroblasts (NHFs)	This study	N/A
Primary cultures of melanocytes (NHMs)	This study	N/A
Primary cultures of keratinocytes (NHKs)	This study	N/A
ex vivo skin explants cultures	This Study	N/A
Oligonucleotides
DKK1 forward GCCTCAGGATTGTGTTGTG	This study	N/A
DKK1 reverse TGTGAAGCCTAGAAGAATTACTG	This study	N/A
EDN1 forward GAAATCATTTGGGTCAACACTC	This study	N/A
EDN1 reverse GGCATCTATTTTCACGGTCTCT	This study	N/A
b-FGF forward CTGGCTTCTAAATGTGTTACGGA	This study	N/A
b-FGF reverse GCCCAGGTCCTGTTTTGGAT	This study	N/A
GAPDH forward TGCACCACCAACTGCTTAGC	This study	N/A
GAPDH reverse GGCATGGACTGTGGTCATGAG	This study	N/A
GDF15 forward CCCATGGTGCTCATTCAAAAG	This study	N/A
GDF15 reverse GCTCATATGCAGTGGCAGTCTT	This study	N/A
IL-1α forward CGCCAATGACTCAGAGGAAGA	This study	N/A
IL-1α reverse AGGGCGTCATTCAGGATGAA	This study	N/A
IL-1β forward CTGAGCTCGCCAGTGAAATG	This study	N/A
IL-1β reverse TTTAGGGCCATCAGCTTCAAA	This study	N/A
IL-6 forward AGCCACTCACCTCTTCAGAACG	This study	N/A
IL-6 reverse GGTTCAGGTTGTTTTCTGCCAG	This study	N/A
IL-8 forward CTTGGCAGCCTTCCTGATTTC	This study	N/A
IL-8 reverse TTCTGTGTTGGCGCAGTGTG	This study	N/A
KGF forward CACCAGGCAGACAACAGACAT	This study	N/A
KGF reverse GTAAGTTCAGTTGCTGTGACGCT	This study	N/A
MITF forward ATGGACGACACCCTTTCTC	This study	N/A
MITF reverse GGAGGATTCGCTAACAAGTG	This study	N/A
MMP1 forward CTGGCCACAACTGCCAAATG	This study	N/A
MMP1 reverse CTGTCCCTGAACAGCCCAGTACTTA	This study	N/A
NRG1 forward AGCCTCAACTGAAGGAGCAT	This study	N/A
NRG1 reverse ACTCCCCTCCATTCACACAG	This study	N/A
POMC forward CTCCCGAGACAGAGCCTCA	This study	N/A
POMC reverse ACTTCCATGGAGGCCTGAAG	This study	N/A
SCF forward AAGAGGATAATGAGATAAGTATGTTGC	This study	N/A
SCF reverse TTACCAGCCAATGTACGAAAGT	This study	N/A
α-SMA forward GCAGCCCAGCCAAGCACTGT	This study	N/A
α-SMA reverse TGGGAGCATCGTCCCCAGCA	This study	N/A
SOX9 forward CACGCTGACCACGCTGAG	This study	N/A
SOX9 reverse TGCTGCTGCTCGCTGTAG	This study	N/A
TYR forward AGCATCCTTCTTCTCCTCCTG	This study	N/A
TYR reverse GCTGAAATTGGCAGTTCTATCC	This study	N/A
VEGF forward GTTGACCTTCCTCCATCC	This study	N/A
VEGF reverse TTCTCTGCCTCCACAATG	This study	N/A
WIF1 forward TACGAAGCCAGCCTCATAC	This study	N/A
WIF1 reverse TGTCGGAGTTCACCAGATG	This study	N/A
WNT 5A forward AGCACGACGAAGCAACCTTG	This study	N/A
WNT 5A reverse GCCCTCTCCACAAAGTGAACAG	This study	N/A
Software and algorithms
CFX Manager™ Software	Bio-Rad Laboratories, Inc.	NA
NineAlliance Software	Uvitec	NA
Other
Sebomed Basal Medium	Merck	Cat#F8205
Dulbecco's Modified Eagle's Medium High Glucose	EuroClone	Cat#ECB7501L
Fetal Bovine Serum Characterized (FBS)	HyClone	Cat#SH30071.03
Cascade Biologics™ Medium 254	Thermo Fisher Scientific	Cat#M-254-500