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Oxford University Press - PMC COVID-19 Collection logoLink to Oxford University Press - PMC COVID-19 Collection
. 2022 Feb 7:ciac110. doi: 10.1093/cid/ciac110

Effectiveness of BNT162b2 and mRNA-1273 Second Doses and Boosters for SARS-CoV-2 infection and SARS-CoV-2 Related Hospitalizations: A Statewide Report from the Minnesota Electronic Health Record Consortium

Paul E Drawz 1,, Malini DeSilva 2, Peter Bodurtha 3, Gabriela Vazquez Benitez 2, Anne Murray 4, Alanna M Chamberlain 5, R Adams Dudley 6, Stephen Waring 7, Anupam B Kharbanda 8, Daniel Murphy 1, Miriam Halstead Muscoplat 9, Victor Melendez 10, Karen L Margolis 2, Lynn McFarling 11, Roxana Lupu 12, Tyler N A Winkelman 3, Steven G Johnson 13
PMCID: PMC8903410  PMID: 35137021

Abstract

Using vaccine data combined with electronic health records, we report that mRNA boosters provide greater protection than a two-dose regimen against SARS-CoV-2 infection and related hospitalizations. The benefit of a booster was more evident in the elderly and those with comorbidities. These results support the case for COVID-19 boosters.

Keywords: vaccine, booster, COVID-19, SARS-CoV-2, hospitalization

Supplementary Material

ciac110_suppl_Supplementary_Material

Associated Data

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Supplementary Materials

ciac110_suppl_Supplementary_Material

Articles from Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America are provided here courtesy of Oxford University Press

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