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Oxford University Press - PMC COVID-19 Collection logoLink to Oxford University Press - PMC COVID-19 Collection
. 2022 Feb 18:jiac053. doi: 10.1093/infdis/jiac053

Characterization of the immune resistance of SARS-CoV-2 Mu variant and the robust immunity induced by Mu infection

Keiya Uriu 1,#, Paúl Cárdenas 2,#, Erika Muñoz 2, Veronica Barragan 2, Yusuke Kosugi 1, Kotaro Shirakawa 3, Akifumi Takaori-Kondo 3, Kei Sato 1,4,; Ecuador-COVID19 Consortium, The Genotype to Phenotype Japan (G2P-Japan) Consortium
PMCID: PMC8903444  PMID: 35176774

Abstract

We have recently revealed that the SARS-CoV-2 Mu variant shows a pronounced resistance to antibodies elicited by natural SARS-CoV-2 infection and vaccination. However, it remains unclear which mutations determine the resistance of SARS-CoV-2 Mu to antiviral sera. Also, it is unclear how SARS-CoV-2 Mu infection induces antiviral immunity. Here we reveal that the two mutations in the SARS-CoV-2 Mu spike protein, YY144-145TSN and E484K, are responsible for the resistance to COVID-19 convalescent sera during early 2020 and vaccine sera. Notably, the convalescent sera of SARS-CoV-2 Mu-infected individuals are broadly antiviral against Mu as well as other SARS-CoV-2 variants of concern/interest.

Keywords: SARS-CoV-2, COVID-19, Mu variant, immune resistance

Supplementary Material

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Associated Data

This section collects any data citations, data availability statements, or supplementary materials included in this article.

Supplementary Materials

jiac053_suppl_Supplementary_Figures
jiac053_suppl_Supplementary_Table_S1
jiac053_suppl_Supplementary_Table_S2
jiac053_suppl_Supplementary_Table_S3
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Articles from The Journal of Infectious Diseases are provided here courtesy of Oxford University Press

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