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Oxford University Press - PMC COVID-19 Collection logoLink to Oxford University Press - PMC COVID-19 Collection
. 2022 Mar 4:rxac016. doi: 10.1093/mrcr/rxac016

Granulomatosis with Polyangiitis Following Pfizer-BioNTech COVID-19 Vaccination

Tsuyoshi Shirai 1,, Jun Suzuki 2, Shimpei Kuniyoshi 3, Yuito Tanno 4, Hiroshi Fujii 5
PMCID: PMC8903471  PMID: 35246689

Abstract

We report the first case of proteinase 3 (PR3)- antineutrophil cytoplasmic antibody (ANCA)-positive granulomatosis with polyangiitis (GPA) with predominant ears, nose, and throat (ENT) manifestations following COVID-19 vaccination. A 63-year-old woman presented with aural fullness three days after vaccination. She presented with progressive rhinosinusitis and otitis media leading to profound hearing loss within three weeks. Clinical imaging revealed soft-tissue shadows in the paranasal sinuses with multiple pulmonary nodules, and histopathology was consistent with a diagnosis of GPA. It is crucial to be wary of the possibility of GPA in patients who received COVID-19 vaccines due to its rapid disease progression.

Keywords: ANCA, COVID-19, granulomatosis with polyangiitis, otitis media, vaccination


Articles from Modern Rheumatology Case Reports are provided here courtesy of Oxford University Press

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