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. 2022 Mar 2;603(7900):343–347. doi: 10.1038/s41586-022-04470-1

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© The Author(s) 2022, corrected publication 2022

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Extended Data Fig. 7 — a, Comparison of 18–20 MM kinked product state Cas9 with a selection of previously determined structures. RMSD between equivalent C-alpha atoms is shown. b, Alignment of HNH from the 18–20 MM kinked product state presented here (transparent grey) and the previously determined ‘post-catalysis’ state (PDB 6O0Y). The catalytically competent HNH conformation between these two structures is highly similar.