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Simplified extracellular matrix structure: three-dimensional macromolecular network composed of various proteins and polysaccharides. The pericellular matrix forms a layer adjacent to the cells: integrins bind to polymerised laminin, which, in turn, is connected via nidogen to the type IV collagen. Interstitial matrix forms porous network of fibrillar collagens, elastic fibres, and proteoglycans.
