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. 2022 Mar 1;11(5):846. doi: 10.3390/cells11050846

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Neural stem cell populations in the spinal cord. Spinal cord derived cells that exhibit stem cell properties include primitive neural stem cells (pNSCs), MSX1+ NSCs, PDK2L1+ CSFcNs and definitive neural stem cells (dNSCs). The lineage relationship (solid arrow) is established between pNSC and dNSC populations. The lineage relationship of MSX1+ NSCs and PDK2L1+ CSFcNs is unknown. The expression profiles listed include genes known to be specific to the identities of a given population (e.g., Oct4, MSX1, and PDK2L1) and those related to their stemness.