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Synthesis of phosphonium salt 284, as reported by Hong et al. [116]. Reagents and conditions: i. LDA (1.3 equiv.); ii. HMPA (1 equiv.), THF, 0 °C, 1 h; iii. CuI (1.2 equiv.), NaI (1.2 equiv.), Cs2CO3 (1.2 equiv.), DMF, rt, overnight; iv. H2, P-2 Ni (1.2 equiv.), (H2NCH2)2 (2 equiv.), MeOH, 0 °C, 4 h, 80%; v. I2 (1.4 equiv.), PPh3 (2.5 equiv.), imidazole (2.5 equiv.), CH2Cl2, rt, 1 h; vi. PPh3 (1 equiv.), MeCN, Δ, overnight, 88%.
