Table 1.
Maternal high-fructose diet-induced adult disease of developmental origins related to gut microbiota dysbiosis in animal models.
| Animal Models | Species/ Gender |
Programming Mechanisms Related to Gut Microbiota | Adverse Offspring Outcomes | References |
|---|---|---|---|---|
| Maternal 60% fructose diet | SD rat/M | Decreased SCFA receptor GPR41 and GPR43 expression | Hypertension | [9] |
| Maternal 10% fructose water | Wistar rat/F | Reduced genera Lactobacillus and Bacteroides | Adiposity, dyslipidemia, and insulin resistance | [10] |
| Maternal 60% fructose diet | SD rat/M | Reduced genus Akkermansia abundance; Increased plasma TMA level | Hypertension | [40] |
| Maternal plus post-weaning 60% fructose diet | SD rat/M | Decreased abundance of genera Lactobacillus, Leuconostoc, and Turicibacter | Hypertension | [41] |
| Maternal 60% fructose diet and minocycline administration | SD rat/M | Reduced α-diversity, Decreased genera abundance of Lactobacillus, Ruminococcus, and Odoribacter; Increased abundance of Akkermansia; Increased SCFA receptor expression | Hypertension | [42] |
SCFA, Short-chain fatty acid. GPR, G protein-coupled receptor. TMA, Trimethylamine.