Table 3.

Blood chemistry at baseline and week 12 in Phase II.

Parameters	Pre-DM (n = 9)			Normal (n = 13)			All (n = 22)
	Week 0	Week 12	p-Value	Week 0	Week 12	p-Value	Week 0	Week 12	p-Value
FBG (mg/dL)	100.22 ± 2.44	95.78 ± 4.02	0.216	86.31 ± 1.71	89.08 ± 1.76	0.175	92 ± 2.04	91.82 ± 2.02	0.924
HbA1C (%)	5.79 ± 0.06	5.5 ± 0.09	0.006 *	5.31 ± 0.05	5.00 ± 0.06	<0.001 *	5.5 ± 0.07	5.2 ± 0.07	<0.001 *
Insulin (µIU/mL)	12.61 ± 2.8	12.77 ± 2.47	0.917	7.28 ± 0.99	7.39 ± 1.09	0.942	9.46 ± 1.37	9.59 ± 1.3	0.931
Total cholesterol (mg/dL)	198.33 ± 7.62	193.67 ± 10.46	0.508	193.31 ± 9.03	190.85 ± 5.87	0.753	195.36 ± 6.07	192 ± 5.37	0.543
HDL	45.22 ± 3.51	46.67 ± 2.74	0.466	52.85 ± 4	54.85 ± 3.62	0.242	49.73 ± 2.83	51.5 ± 2.52	0.156
LDL	132.33 ± 6.82	125.33 ± 8.51	0.252	121.46 ± 7.91	115.46 ± 5.32	1.000	125.91 ± 5.45	119.5 ± 4.69	0.247
Triglyceride	104.11 ± 15.35	107 ± 18.81	0.857	94.46 ± 15.38	102.15 ± 12.22	0.196	98.41 ± 10.85	104.14 ± 10.28	0.385
AST	21 ± 2.39	22.22 ± 2.38	0.522	18.23 ± 1.6	21.46 ± 3.09	0.141	19.36 ± 1.36	21.77 ± 2.03	0.139
ALT	29.22 ± 5.01	35.11 ± 8.01	0.319	19.08 ± 2.98	18.69 ± 3.36	0.783	23.23 ± 2.84	25.41 ± 4.11	0.723
BUN	10.67 ± 0.5	10.78 ± 0.88	0.834	11.23 ± 1.2	10.04 ± 0.75	0.321	11 ± 0.73	10.34 ± 0.56	0.674
Creatinine	0.8 ± 0.05	0.79 ± 0.04	0.434	0.78 ± 0.05	0.79 ± 0.04	0.655	0.79 ± 0.03	0.79 ± 0.03	0.971
eGFR	110.78 ± 4.8	111.11 ± 3.92	0.831	111.15 ± 3.61	111.85 ± 3	0.827	111 ± 2.83	111.55 ± 2.33	0.776

* significant value less than 0.05. Data are presented as mean ± SEM