Author response image 1. Correlation between membrane thickness and the free energy barrier for creating a 3-nm-radius pore in a lipid bilayer.

Each dot corresponds to one of 18 monocomponent coarse-grained Martini membranes, made from fully saturated and monounsatured lipids with different chain lengths and different headgroups (PC, PE, PS, and PG). Reproduced from data tabulated in (Hu et al., 2015).